Motilium (Generic name: Domperidone) is a prescription medicine that increases the movements or contractions of the stomach and bowel. Motilium is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's disease. Domperidone is a dopamine antagonist works by blocking the action of a chemical messenger in the brain which causes the feeling of nausea and vomiting, as well as increasing the movement or contractions of the stomach and intestines, allowing food to move more easily through the stomach. Your doctor may prescribe Motilium for other medical purposes that not listed here. Take Motilium exactly as it was prescribed for you. FDA Alert on Motilium (Domperidone): How to request Domperidone for gastrointestinal disorders
The most common Motilium side effects are abdominal cramps, constipation, diarrhea, dry mouth, dizziness, headache, heartburn, insomnia, itchy rash, nausea, and hormonal effects (e.g., breast enlargement, tenderness, production of milk and irregular menstruation). If you are experiencing any severe side effects such as abnormal urination, irregular heartbeat, loss of balance, muscle cramps, and serious allergic reaction (e.g., swelling of face, hands, mouth, legs or feet), please inform your doctor immediately.
You should follow the instructions of the doctor who prescribed Motilium to you. Directions and dosage information can also be found on the pack or leaflet inside the pack. Motilium comes in tablet form. You should swallow Motilium whole with a glass of water. Motilium can be taken with or without food. It is safe to take up to 4 tablets in a 24 hour period, and it is advised to take one of these at night before bed. Motilium should be stored at room temperature away from direct sunlight and heat.
You should follow the instructions of the doctor who prescribed Motilium to you. Directions and dosage information can also be found on the pack or leaflet inside the pack. Motilium comes in tablet form. You should swallow Motilium whole with a glass of water. Motilium can be taken with or without food. Motilium should be stored at room temperature away from direct sunlight and heat. Domperidone may be associated with a small increased risk of serious ventricular arrhythmias or sudden cardiac death. A higher risk was observed in patients: • older than 60 years of age; • using daily doses greater than 30 mg; • having predisposing factors for QT prolongation including concomitant use of QT-prolonging drugs or CYP 3A4 inhibitors. • Domperidone is now contraindicated in patients: • with prolongation of cardiac conduction intervals, particularly QT; • with significant electrolyte disturbances; • with cardiac disease (such as congestive heart failure); • with moderate or severe liver impairment; • receiving QT-prolonging drugs and potent CYP3A4 inhibitors. Domperidone should be used at the lowest effective dose to a maximum recommended daily dose of 30 mg and for the shortest possible duration.
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