
from stevendepolo
Researchers based out of the B.C. Cancer Agency’s Deeley Research Centre have stated they are that much closer to creating a vaccine to fight ovarian cancer. This new vaccine would work differently then the usual preventative vaccine.
Ovarian cancer, the most severe of the gynecological cancers, kills over 1700 Canadian women annually. Ovarian cancer affects the ovaries, the egg-producing centers in women’s bodies. If left undiagnosed, cancerous cells are often shed from the ovaries, affecting the organs and structures around them, such as the uterus, bladder and bowel.
Currently, no screening tools, (such as a mammogram for breast cancer) are available for ovarian cancer. What symptoms there are are often vague and easily missed. Because of this, ovarian cancer is often missed until it is in advanced stages; where it often has adversely affected other parts of the body.
Ovarian cancer is usually treated in stages, starting with tumor removal. After the cancerous tumor is surgically removed, the patient undergoes intense chemotherapy sessions. This often knocks back the cancerous cells, but many patients see a relapse in two to three years.
Researchers would ideally use the vaccine at this point, after chemotherapy, when the cancerous cells are at their weakest, with the lowest count. The Deeley Research vaccine would work by educating the patient’s own immune system to attack the cancerous cells. They would tailor each patient’s vaccine by using cells from their tumor. This provides a more targeted attack on the mutated cells.
If the cancerous cells again mutate, another targeted vaccine could be easily created, says Brad Nelson, project leader, and a cellular and molecular biologist. “There really is no limit to how long you can play this strategy.”
Although researchers are three to five years away from clinical trials, the formula is sound. The vaccine will target five of the cancer cells various mutations. The chance that the cancer virus is able to bypass all five attacks by the body’s immune system is low.