Archive for the ‘Antipsychotic’ Category

Hoarding Four Times More Common than Bi-Polar Disorder

Tuesday, October 25th, 2011

Magazine Hoarding

Recent studies suggest an estimated two to five percent of Americans are hoarders, or between 6 to 15 billion people. That’s twice as many people as have obsessive compulsive disorder, and four times as many as are diagnosed with bi-polar disorder or schizophrenia.

People who hoard have a strong emotional attachment to things many of us see as unimportant, or even junk. They perceive a beauty or value in their “junk” that others do not see, and often keep something because they feel it may “come in handy” one day. Giving or, worse yet, throwing these items away causes a deep sense of loss.

In a recent article on the treatment of hoarding, Suzanne Otte, MBA, MSW and Gail Steketee, PhD theorized that “a combination of early experiences and cognitive challenges result in mistaken beliefs about and attachments to possessions, with resulting negative emotions that lead to avoidance behaviors (saving unneeded items) and clutter. In addition, objects that evoke feelings of positive attachment and experiences of pleasure may result in excessive acquiring and clutter.”

No one is sure why, but there are more male than female hoarders. Hoarding symptoms typically arise in the teen-age years, but most hoarders don’t seek help until after they turn 40. Hoarding is differentiated from “collecting” by:
• Acquiring many items, but never disposing of any of them
• A living space that is so cluttered it can no longer be used as it was intended to be
• Significant stress or impaired functioning related to the hoarding

Until recently, hoarding was considered a form of obsessive compulsive disorder (OCD). But according to psychologist and hoarding specialist David Tolin, PhD, “As we have more studies coming in, we’re increasingly seeing that it’s not. In fact, Tolin says, “It seems like there is not a particular special or strong relationship with OCD. Much more common are problems like major depression disorder, anxiety, and attention deficit disorder.”

Hoarding is now under consideration for inclusion in DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) as a stand-alone disorder, but it often occurs alongside another disorder. A recent study of 217 hoarders found that more than 50% of them also suffered from major depression, and almost 25% experienced generalized or social phobia. Less than 20% were also diagnosed with OCD. Interestingly, 10% were also identified as kleptomaniacs.

Most hoarders have little insight into the depth and impact of their disorder, which greatly frustrates their family, friends, and community. Hoarders may not seek treatment until outside agencies take action in the form of an eviction notice, the removal of a child from the home, or an order from the health or fire department to clean up the property.

Hoarding is very resistant to treatment. “When it comes to chronic and severe problems like drug use, bipolar disorder, severe depression, or hoarding,” Tolin says, “Even with the best of treatment, a lot of people will still be struggling.” Because of that, many therapists concentrate on “harm reduction” rather than healing – such as eliminating vermin, meeting fire and health standards, and decluttering the yard to appease the neighbors.

Hoarding is usually treated with a combination of therapy and depression medication. Cognitive behavior therapy (CBT) – a structured therapy that seeks to change unwanted behaviors and emotions by identifying and replacing the underlying negative and inaccurate thoughts and beliefs – is the treatment of choice for hoarding, with a 70% to 80% clinical improvement rate for those who complete therapy.

The prescription antidepressants most commonly prescribed to treat hoarding are selective serotonin reuptake inhibitors (SSRIs), such as escitalopram oxalate (Lexapro) and paroxetine (Paxil).

Given the recently established links between hoarding, depression and anxiety, it’s not surprising that CBT and anti-depression medication are leading treatments for all three conditions.

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Off-Label Use of Antipsychotic Drugs Is Controversial

Friday, October 14th, 2011

from Anael Raziel

Expensive antipsychotic drugs such as Abilify and Seroquel are the top-selling category of drugs in the US, and are continuing to increase their market share as off-label add-ons to other medications. The newer atypical antipsychotics (also called second-generation antipsychotics) are being increasingly prescribed for the treatment of dementia, anxiety, post-traumatic stress disorder, attention-deficit hyperactivity disorder, and other conditions.

“Off-label” is the term used when doctors prescribe medications for other than their FDA-approved uses. Off-label use is rising despite an updated analysis that found that antipsychotic medication’s helpfulness in non-approved uses is minimal, and the risk of side effects is significant, including weight gain, metabolic problems, fatigue, tremors, urinary tract symptoms and even stroke.

According to Medscape, recent data shows that several illnesses don’t respond at all to antipsychotic drugs, including eating disorders and drug and alcohol abuse. The evidence for treatment of post-traumatic stress disorder and personality disorders is inconclusive.

A few off-label uses were supported by the new data. Anxiety patients got moderate benefit from Seroquel (generic quetiapine), and obsessive compulsive disorder patients responded to treatment with Risperdal (generic risperidone). Elderly patients with dementia also saw a small benefit from taking antipsychotics.

“This systematic review demonstrates evidence for the efficacy of atypical antipsychotic medications for only a few of the off-label conditions that are currently being treated,” wrote Dr. Alicia Ruelaz Maher, lead author of the study, published in the Journal of the American Medical Association, “We need to use this information and be wary of prescribing when it isn’t warranted.”

Many have been questioning the increasing off-label use of atypical antipsychotics for some time, including the US Department of Justice. The Justice Department investigated four major pharmaceutical companies in three years for their aggressive marketing of anti-psychotics for off-label use, including use in children and the elderly.

Doctors are allowed to prescribe any approved drug for off-label uses, but it is illegal for drug companies to promote medications for any purpose not specifically approved by the FDA. Each of the drug companies paid hundreds of millions to settle the cases against them.

The more cynical of the critics of the off-label use of antipsychotics suggest Big Pharma is pushing the use of expensive, newer-generation atypicals to make up for lost earnings on name brand antidepressant medications that have or soon will be going generic. According to the Decision Resources Group, the antidepression drug market will decrease almost $2 billion by 2020, dropping to $9.8 billion from 2010′s $11.6 billion.

The FDA has approved several antipsychotic drugs to treat major depressive disorder in recent years, including Seroguel XR and Abilify (generic aripiperazole). Less costly generic Seroquel XR and generic Abilify are available over the internet through an online Canadian pharmacy.

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Revolutionary New Blood Tests for Depression and Schizophrenia

Wednesday, August 24th, 2011

Evan Rachel blood shot

A San Diego neurodiagnostic company has developed the first blood test for depression. The revolutionary test, called MDDScore, was described in a cover story of the August 2011 Psychiatric Times, along with two other leading edge diagnostic technologies.

The simple blood test, developed and marketed by Ridge Diagnostics, uses biological markers and sophisticated diagnostic algorithms to identify major depressive disorders and other mental health conditions. The company also has a second test intended to monitor and measure the effectiveness of treatment with antidepressant medication in clinical trials.

Ridge Diagnostics Chief Executive Officer Lonna J. Williams hopes the new diagnostic tool will help remove barriers to the diagnosis and treatment of depression, saying “By having a biological indication of depression, patients and their families have a better understanding of the condition as a medical one, which reduces the stigma of mental health disorders and leads to an improvement in health compliance.”
(more…)

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Canadian Pharmacies Wary Of Stocking Antipsychotic Drugs That Spell Danger to Newborn Babies

Friday, June 24th, 2011

Safety of Antipsychotic Drugs

There is definite risk associated with antipsychotic drugs given to pregnant women, especially in the third trimester, which has already made Canadian pharmacies wary of stocking drugs without safety information available on the label.

Health Canada highlighted the potential risks involved in a recent release published in June 2011 and has already taken the necessary steps to indicate those including withdrawal symptoms and abnormal muscle movements in newborn babies. Pregnant women had to be aware of potential risks, and until a perfect system is in place, they must be in a position to seek alternate medication in consultation with their doctors to prevent impending danger to the newborn infant.

Antipsychotic medications are usually prescribed for schizophrenia or bipolar disorder. Both these medical conditions are related to imbalances in the mind. Schizophrenia occurs when a person is unable to distinguish between situations occurring in the imaginary and real world. Logical thinking is affected, and they are unable to behave normally without having emotional outbursts.
(more…)

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Antipsychotics – The Top-Selling Prescription Drug in the US

Thursday, January 20th, 2011

If asked to guess what the top-selling prescription drug in the US is, few people would answer antipsychotic medication. Surprisingly, and perhaps disturbingly, antipsychotics are the most commonly prescribed class of medications in the United States, with prescription sales of $14.6 billion in 2009.

Antipsychotics are typically prescribed to treat psychosis, primarily in schizophrenia and bi-polar disorder, although they are increasingly used to treat non-psychotic disorders such as Tourette syndrome and even autism. (more…)

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Powerful Atypical Antipsychotics Used to Treat Schizophrenia, Bipolar Disorder and Autism

Monday, November 22nd, 2010

Schizophrenia is a severe, disabling mental illness characterized by disruptions in thinking and emotional responses. Sufferers often experience psychosis –a disconnection from reality characterized by delusions, hallucinations and disordered thinking. Schizophrenia affects about one percent of the population, or 2 million Americans.  Typically, the illness strike males in late adolescence or early adulthood, and females in their late twenties or early thirties. There are five main types of schizophrenia:

1)    Paranoid schizophrenia – characterized by suspicion, and hallucinations and delusions of being persecuted.

2)    Disorganized schizophrenia – involves incoherent and disorganized speech, emotions and behavior.
(more…)

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Schizophrenia and Bipolar Disorder: Getting the Right Diagnosis and Psychiatric Medications

Friday, September 3rd, 2010

Understanding the difference between Schizophrenia and Bipolar Disorder is the key to getting the right diagnosis and treatment. These two conditions are very different with the only similarity being social stigma. If you or a loved one has been diagnosed with Schizophrenia or Bipolar disorder you know it can be a confusing moment as you may not understand what these two disorders entail. These are life-long disorders that require a combination of mental therapy and psychiatric medications; finding the right combination of therapies can be tricky, but with the right information and support system rehabilitation can be a success.

Understanding what constitutes Schizophrenia can facilitate your diagnosis; there are mild to severe cases and not all individuals will experience the same symptoms with the same intensity. Schizophrenia is a condition first diagnosed in a person’s late teens and early 20′s; men are more commonly diagnosed than women. (more…)

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