Archive for the ‘Depression’ Category

Experimental Drug More Effective than Aspirin in Preventing Repeat Strokes

Monday, February 6th, 2012

by Reuters

New drug apixaban, although not yet approved by the FDA, studies are indicating promise for the drug to cut clot risk caused by abnormal heartbeat.

According to a new study funded by Bristol-Myers Squibb and Pfizer the investigational drug apixaban (Eliquis), appears to be better than aspirin at preventing blood clots in certain patients who have already suffered a stroke a “mini-stroke” due to abnormal heart rhythm.

The team of researchers from Canada and Germany, led by Dr. Hans-Christoph Diener of the University Hospital Essen, tracked nearly 5600 atrial fibrillation patients (average age of 70) for about one year. All of the patients selected were deemed unsuitable for standard treatment with the anticoagulant known as warfarin.

The study participants were randomly divided into two groups: one group received two daily doses of 5 mg’s of apixaban, and the other group received between 81-324 mg’s of aspirin daily.

The result
Among those taking apixaban who had a prior history of stroke or mini-stroke, only 2.4% had a subsequent stroke or systemic embolism (blood clot) during the treatment. However, of the participants who were taking the aspirin the figure rose to 9%.

It was concluded that apixaban was well-tolerated and afforded a greater measure of stroke risk reduction than aspirin.

For the time being, Apixaban is currently under review for approval by the United States Food and Drug Administration. All of the finding and data that were retrieved were slated for presentation at the American Stroke Association’s annual conference in New Orleans.

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Are You Working Too Hard? It May Lead to Depression

Monday, January 30th, 2012

Depression from excessive job stress

A new study has found that frequent overtime can lead to depression. Employees who work frequent overtime are twice as likely to have a “major depressive episode” than employees who online work an eight hour day.

The study followed 1200 British civil servants for 6 years. It concluded that those employees who consistently worked overtime (hours more than the regular 7-8) were more prone to depression and mania.

Sure, your wallet is full, so that probably making you happy, but always coming home late, or working on weekends, is taking its toll on your emotional health. Also noted in the article was the addition of changing work hours was also detrimental to personal health. Shift work, combined with overtime, is leading to depression, and ill health in many people.

“That changing pattern strongly predicts mood episodes, both depressive episodes, but also manic episodes in people who are vulnerable to bipolar disorder”, says Kate Harkness, a Queen’s University psychology professor. But, this negative pattern may be counteracted with strict scheduling of sleep, eating, and exercise. Cyclic patterns are thought to help maintain a sense of regularity, and thus lower stress levels.

For more information, click here.

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Hoarding Four Times More Common than Bi-Polar Disorder

Tuesday, October 25th, 2011

Magazine Hoarding

Recent studies suggest an estimated two to five percent of Americans are hoarders, or between 6 to 15 billion people. That’s twice as many people as have obsessive compulsive disorder, and four times as many as are diagnosed with bi-polar disorder or schizophrenia.

People who hoard have a strong emotional attachment to things many of us see as unimportant, or even junk. They perceive a beauty or value in their “junk” that others do not see, and often keep something because they feel it may “come in handy” one day. Giving or, worse yet, throwing these items away causes a deep sense of loss.

In a recent article on the treatment of hoarding, Suzanne Otte, MBA, MSW and Gail Steketee, PhD theorized that “a combination of early experiences and cognitive challenges result in mistaken beliefs about and attachments to possessions, with resulting negative emotions that lead to avoidance behaviors (saving unneeded items) and clutter. In addition, objects that evoke feelings of positive attachment and experiences of pleasure may result in excessive acquiring and clutter.”

No one is sure why, but there are more male than female hoarders. Hoarding symptoms typically arise in the teen-age years, but most hoarders don’t seek help until after they turn 40. Hoarding is differentiated from “collecting” by:
• Acquiring many items, but never disposing of any of them
• A living space that is so cluttered it can no longer be used as it was intended to be
• Significant stress or impaired functioning related to the hoarding

Until recently, hoarding was considered a form of obsessive compulsive disorder (OCD). But according to psychologist and hoarding specialist David Tolin, PhD, “As we have more studies coming in, we’re increasingly seeing that it’s not. In fact, Tolin says, “It seems like there is not a particular special or strong relationship with OCD. Much more common are problems like major depression disorder, anxiety, and attention deficit disorder.”

Hoarding is now under consideration for inclusion in DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) as a stand-alone disorder, but it often occurs alongside another disorder. A recent study of 217 hoarders found that more than 50% of them also suffered from major depression, and almost 25% experienced generalized or social phobia. Less than 20% were also diagnosed with OCD. Interestingly, 10% were also identified as kleptomaniacs.

Most hoarders have little insight into the depth and impact of their disorder, which greatly frustrates their family, friends, and community. Hoarders may not seek treatment until outside agencies take action in the form of an eviction notice, the removal of a child from the home, or an order from the health or fire department to clean up the property.

Hoarding is very resistant to treatment. “When it comes to chronic and severe problems like drug use, bipolar disorder, severe depression, or hoarding,” Tolin says, “Even with the best of treatment, a lot of people will still be struggling.” Because of that, many therapists concentrate on “harm reduction” rather than healing – such as eliminating vermin, meeting fire and health standards, and decluttering the yard to appease the neighbors.

Hoarding is usually treated with a combination of therapy and depression medication. Cognitive behavior therapy (CBT) – a structured therapy that seeks to change unwanted behaviors and emotions by identifying and replacing the underlying negative and inaccurate thoughts and beliefs – is the treatment of choice for hoarding, with a 70% to 80% clinical improvement rate for those who complete therapy.

The prescription antidepressants most commonly prescribed to treat hoarding are selective serotonin reuptake inhibitors (SSRIs), such as escitalopram oxalate (Lexapro) and paroxetine (Paxil).

Given the recently established links between hoarding, depression and anxiety, it’s not surprising that CBT and anti-depression medication are leading treatments for all three conditions.

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Anti-inflammatories as Depression Medication?

Monday, August 29th, 2011

Great Depression

Marcelle Pick, OB-Gyn, an author and health show host, says it’s fascinating to watch the western medical community “discover” inflammation, an understanding of which she says is “old hat” in Eastern medicine. An increasing number of studies have linked chronic inflammation to a host of common and serious diseases including cancer, arthritis, allergies, asthma, diabetes, colitis, Parkinson’s and Alzheimer’s. Inflammation is so closely connected to heart disease that many doctors now test for the critical inflammatory marker C-reactive protein to aid them in a diagnosis.

But even Dr. Pick might be surprised to learn of the latest condition to be associated with inflammation – suicidal depression. McGill University’s Group for Suicide Studies in Montreal, Canada, compared the brains of suicide victims to those who had died suddenly of other causes. Their findings led support to their theory that inflammation in the brain plays a key role in depression. (more…)

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Revolutionary New Blood Tests for Depression and Schizophrenia

Wednesday, August 24th, 2011

Evan Rachel blood shot

A San Diego neurodiagnostic company has developed the first blood test for depression. The revolutionary test, called MDDScore, was described in a cover story of the August 2011 Psychiatric Times, along with two other leading edge diagnostic technologies.

The simple blood test, developed and marketed by Ridge Diagnostics, uses biological markers and sophisticated diagnostic algorithms to identify major depressive disorders and other mental health conditions. The company also has a second test intended to monitor and measure the effectiveness of treatment with antidepressant medication in clinical trials.

Ridge Diagnostics Chief Executive Officer Lonna J. Williams hopes the new diagnostic tool will help remove barriers to the diagnosis and treatment of depression, saying “By having a biological indication of depression, patients and their families have a better understanding of the condition as a medical one, which reduces the stigma of mental health disorders and leads to an improvement in health compliance.”
(more…)

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Facts about Men in Depression

Thursday, August 4th, 2011

Depressed man

Depression in men is a fact that cannot be ignored, and Canadian internet pharmacy reveals some facts about why it strikes men, in what way, and triggers they need to be aware of. A condition that affects the mind, depression does not spare anyone likely to get tense over matters within or out of their control.

Men cannot ignore depression, as it can lead to family, financial, and personal hardships over a period of time. Limits of tolerance are extended to the fullest, and family members and friends often believe it is best to ignore a depressed person when the sufferer does not take substantial steps to come out of the state.
(more…)

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Melatonin Based Depression Medication in US Clinical Trials

Wednesday, June 1st, 2011

Photo: New Antidepressant Drug

A new class of antidepressant based on the hormone melatonin appears to offer more benefits and fewer side effects than current antidepressant medications.

Depression sufferers, in particular those who don’t respond to current antidepressants, may benefit from a new class of depression medication based on melatonin. A new European antidepressant which both binds to melatonin and blocks serotonin is proving to be an effective treatment for both depression and sleep disorders. Most people who suffer from depression also experience sleep disturbances.
(more…)

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Compelling New Evidence for Genetic Link to Depression

Friday, May 20th, 2011

Two separate studies lining the same chromosome to depression put us on the road to understanding the root cause of depression, and hopefully, developing more effective antidepressant medications.

In a compelling coincidence, two separate groups of researchers working independently have connected the same region of DNA to depression. The region contains almost 100 genes, and it’s believed multiple genes are linked to major depression.
(more…)

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Painkillers May Reduce Effectiveness of Depression Medication

Monday, May 2nd, 2011

Researchers at New York’s Rockefeller University have made a surprise finding that could impact the millions of Americans who are taking antidepressant medication called selective serotonin reuptake inhibitors, or SSRIs. Commonly prescribed SSRI antidepressants include Prozac, Paxil, Lexapro and Zoloft.

The researchers discovered a potential interaction between antidepressant medication and commonly prescribed painkillers known as NSAIDs (nonsteroidal anti-inflammatory drugs) that appeared to reduce the antidepressant’s effectiveness. Commonly used NSAIDs include aspirin, naproxen and ibuprofen. (more…)

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Depression May Be In Our Genes But Help from Online Canadian Pharmacies

Thursday, January 13th, 2011

New research has shown that our genes may be partially responsible for how likely we are to developing and suffering from depression in a study by University of Michigan Health System scientists. (more…)

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