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Get Curanail Nail Lacquer 5%/5 ml from the United Kingdom by Galderma

The brand Curanail nail lacquer 5% (Loceryl nail lacquer) comes from the United Kingdom manufactured by Galderma. It is available in the quantity of one, 5 ml bottle.

Curanail (Amorolfine) Information

Curanail (amorolfine) is a topical antifungal agent belonging to the morpholine class of chemicals. It is typically formulated as a 5% nail lacquer. It is indicated for the treatment of mild to moderate onychomycosis (fungal nail infection) caused by dermatophytes, yeasts, and moulds, often affecting the toenails and fingernails. Curanail 5% nail lacquer is available over-the-counter (without a prescription) in Canada and many other regions for adults. It is designed to penetrate the hard nail plate and the nail bed where the fungal infection resides. It is applied directly to the infected nail once a week. It requires a long treatment duration—typically six months for fingernails and nine to twelve months for toenails—reflecting the slow growth rate of the nail and the persistent nature of the infection.

The mechanism of action for amorolfine involves disrupting the integrity of the fungal cell membrane, leading to fungal death. Amorolfine achieves this by blocking key steps in the production of ergosterol, the primary fatty substance required to build the fungal cell wall. Specifically, the drug has a unique, multi-target action: it interferes with the enzymes delta-14-sterol reductase and delta-7-8 isomerase, and in some fungal species, it also inhibits squalene epoxidase. By preventing the fungus from making vital ergosterol, amorolfine causes the accumulation of an abnormal, toxic sterol called ignosterol within the fungal cell membrane. This profoundly disrupts the membrane's structure, permeability, and function, thereby achieving a broad-spectrum fungicidal (killing) effect. Because Curanail is a topical lacquer, systemic absorption is extremely low, limiting the potential for widespread drug interactions or systemic side effects.

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Do I need a prescription to order Curanail 5 %/5 ml ?

Yes, a prescription is required from your physician to order Curanail 5 %/5 ml.