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Best Price on Daraprim 25 mg from Australia by Aspen

The brand Daraprim 25 mg comes from Australia by Aspen. It is available in the quantity of 30 and 90 tablets.

Daraprim (Pyrimethamine) Information

Daraprim (pyrimethamine) is an orally administered antiparasitic compound that acts as a potent folic acid antagonist. It is a cornerstone medication, typically used in combination with a sulfonamide (such as sulfadiazine) and often with folinic acid (leucovorin), for the treatment of specific protozoal infections. Daraprim is primarily indicated for the acute and chronic treatment of toxoplasmosis, including ocular infections and congenital toxoplasmosis, particularly in immunodeficient patients such as those with HIV/AIDS. It is also an FDA-approved antimalarial agent for treating chloroquine-resistant P. falciparum malaria when used with another agent, and for certain forms of prophylaxis. However, it is not recommended for malaria prophylaxis for travellers in any region due to global widespread parasite resistance. The dosage required for toxoplasmosis treatment is substantially higher (10 to 20 times) than the dose used for malaria prophylaxis, which places it close to its toxic level, necessitating highly cautious and carefully monitored administration. The co-administration of leucovorin is vital to serve as a rescue agent that protects human bone marrow cells from pyrimethamine's toxic effects.

The mechanism of action for pyrimethamine centers on its role as a selective dihydrofolate reductase (DHFR) inhibitor. It competitively inhibits the DHFR enzyme, which is necessary for the regeneration of tetrahydrofolic acid from dihydrofolate. Tetrahydrofolic acid is an essential cofactor for the synthesis of nucleic acids (DNA and RNA) and proteins. The rationale for its therapeutic action is based on the differential requirement between the human host and the parasite (Toxoplasma gondii or Plasmodium species) for these precursors. Pyrimethamine exhibits a far greater affinity for the protozoal DHFR enzyme than for the human enzyme. This effectively starves the parasite of the folic acid derivatives necessary for growth and reproduction, thereby halting the infection. Pyrimethamine is well absorbed following oral administration and is eliminated slowly, with a half-life of approximately 80 to 95 hours.

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Do I need a prescription to order Daraprim 25 mg ?

Yes, a prescription is required from your physician to order Daraprim 25 mg.