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Brand Loceryl Nail Lacquer 5 ml from the UK by Galderma

Bigmountaindrugs.com offers the brand Loceryl nail lacquer from the United Kingdom by Galderma. It is available in the quantity of one, 5 ml bottle.

Loceryl Nail Lacquer (Amorolfine) Information

Loceryl Nail Lacquer (amorolfine), an antifungal agent belonging to the morpholine class, is formulated as a 5% nail lacquer. It is specifically indicated for the treatment of mild to moderate onychomycosis (fungal nail infection) affecting the fingernails and toenails, caused by dermatophytes, yeasts, and moulds. This medication is typically available over-the-counter (OTC). Loceryl is designed to create a drug reservoir within the nail, allowing the medication to penetrate the hard nail plate and reach the nail bed where the fungal infection is established. The treatment regimen requires once-weekly application for an extended duration—typically six months for fingernails and nine to twelve months for toenails—due to the slow growth rate of nails.

The mechanism of action for amorolfine is fungicidal (killing the fungus). It is highly effective due to its interference with the fungal cell membrane. Amorolfine achieves this by blocking key steps in the production of ergosterol, the primary fatty substance required to build the fungal cell wall. Specifically, the drug has a unique, multi-target action: it interferes with the enzymes delta-14-reductase and delta-7-isomerase, and in some fungal species, it also inhibits squalene epoxidase. By preventing the fungus from manufacturing vital ergosterol, amorolfine causes the accumulation of an abnormal, toxic sterol called ignosterol within the fungal cell instead. This severely compromises the membrane's structure, permeability, and function, leading directly to the death of the fungal organism. Because Loceryl is a topical lacquer, systemic absorption is extremely low.

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Do I need a prescription to order Loceryl Nail Lacquer 5 ml ?

Yes, a prescription is required from your physician to order Loceryl Nail Lacquer 5 ml.