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Brand Primaquine 26.3 mg from Canada by Sanofi Aventis

Bigmountaindrugs.com offers the brand Primaquine 26.3 mg from Canada manufactured by Sanofi Aventis. It is available in the quantity of 100 tablets.

Primaquine (Primaquine Phosphate) Information

Primaquine (primaquine phosphate) is a foundational 8-aminoquinoline antimalarial medication, historically developed to combat the persistent forms of malaria. It is the only widely available drug, besides tafenoquine, indicated for the radical cure (prevention of relapse) of malaria caused by Plasmodium vivax and Plasmodium ovale. These species are characterized by dormant liver stages, known as hypnozoites, which cause recurring illness months or years after the initial infection. Primaquine is also crucial for transmission blocking, using a single low dose (SLD) to sterilize the infectious sexual forms of all Plasmodium species, especially P. falciparum. Dosing is carefully determined based on the patient's weight and species of parasite. Treatment must always be preceded by or concurrent with a blood schizonticide (like chloroquine or an ACT) to treat the acute phase of the illness.

The unique mechanism of action for primaquine centers on its status as a prodrug. It must be metabolized in the liver, primarily by the cytochrome P450 enzyme CYP2D6, into active, highly oxidizing metabolites. These metabolites are believed to generate reactive oxygen species (ROS) and interfere with mitochondrial respiration in both the hypnozoites (in the liver) and the gametocytes (in the blood). This oxidative process destroys the parasites, thereby preventing relapse and blocking transmission. The drug must be taken with food to enhance its oral bioavailability and reduce gastrointestinal side effects. The standard regimen for radical cure is 15 milligrams base daily for 14 days.

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Do I need a prescription to order Primaquine 26.3 mg ?

Yes, a prescription is required from your physician to order Primaquine 26.3 mg.