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Brand Zirgan Eye Gel 0.15%/5 gm from United Kingdom

The brand Zirgan Eye Gel (Virgan) 0.15%/5 gm comes from United Kingdom. It is available in the quantity of one and three, 5 gm eye gel.

Zirgan Information

Zirgan (Ganciclovir) is primarily indicated for the treatment of acute herpetic keratitis, specifically when presenting as dendritic ulcers. These are eye infections caused by the herpes simplex virus (HSV). While ganciclovir is well-known in its systemic form for treating cytomegalovirus, Zirgan offers a targeted approach for the eye that is generally better tolerated than some older alternatives. The medication contains ganciclovir 0.15% in a sterile ophthalmic gel. It belongs to the antiviral class, specifically a purine nucleoside analog (guanosine derivative). This eye solution works as a pro-drug that remains largely inactive until it enters a virus-infected cell. Once inside, viral enzymes (specifically thymidine kinases) phosphorylate the ganciclovir into its active form, ganciclovir triphosphate. This active compound then sabotages the virus in two ways: it competitively inhibits viral DNA polymerase and embeds itself into the viral DNA strand, effectively acting as a chain terminator that halts replication. Because it relies on viral enzymes for this activation, it tends to be quite selective, sparing healthy corneal cells from the toxicity often seen with older antivirals.

Herpetic keratitis is an infection caused by the herpes simplex virus, which wakes from dormancy in the trigeminal nerve and travels to the cornea. This often results in a dendritic ulcer, a distinct, branch-like lesion on the clear front surface of the eye that can cause significant pain, light sensitivity, and blurred vision. If left untreated, these ulcers can lead to permanent scarring or even corneal perforation. Zirgan essentially puts the brakes on the viral wildfire, preventing the virus from copying its genetic material. This stabilization allows the corneal epithelium to grow back over the ulcerated area, significantly reducing the risk of long-term vision loss and the need for more invasive treatments such as corneal transplants.

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Do I need a prescription to order Zirgan 0.15 %/5 gm ?

Yes, a prescription is required from your physician to order Zirgan 0.15 %/5 gm.