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Actoplus Met (Pioglitazone/Metformin) Information

Actoplus Met, which contains pioglitazone and metformin, is an oral medication used to control blood sugar levels in adults with type 2 diabetes. It helps lower blood sugar by improving the body’s response to insulin and by reducing the amount of sugar produced by the liver. Actoplus Met is usually taken once or twice daily and is often prescribed when metformin alone is not enough. Combining these two medicines helps control blood sugar over the long term and lowers the risk of diabetes-related complications.

The mechanism of action involves the dual activity of its components. Pioglitazone works by increasing the body’s sensitivity to insulin, allowing muscles and fat tissues to use glucose more effectively. This reduces insulin resistance, a core problem in type 2 diabetes. Metformin decreases the amount of glucose produced by the liver, improves insulin sensitivity, and slightly reduces intestinal glucose absorption. Together, these actions help maintain more stable blood glucose levels throughout the day and support better metabolic control.

Actoplus Met Side Effects

Actoplus Met is generally well-tolerated, but some common side effects may occur. Commonly reported effects include stomach upset, diarrhea, gas, nausea, and mild abdominal discomfort due to the metformin component. Some people may also experience weight gain, ankle swelling, or mild fatigue related to pioglitazone. Headache, dizziness, or upper respiratory symptoms may also occur.

More serious side effects can occur and require immediate medical attention. Stop taking the medication and seek help if you experience:
• Liver problems, including yellowing of the skin or eyes, dark urine, or persistent nausea
• Severe allergic reactions, including rash, swelling of the face or throat, or difficulty breathing
• Signs of possible heart failure, including sudden shortness of breath, rapid weight gain, or swelling
• Symptoms of lactic acidosis, including extreme weakness, rapid breathing, drowsiness, muscle pain, or severe stomach discomfort
• Unusual bone fractures
• Vision changes or new eye swelling

Actoplus Met Precautions

Do not use Actoplus Met if you are allergic to metformin, pioglitazone, or any component of the tablets. It should not be used in people with severe kidney disease, metabolic acidosis, or active bladder cancer. Before starting treatment, inform your doctor of your complete medical history. People with heart failure, liver problems, anemia, chronic alcohol use, bone weakness, or swelling in the extremities may require special monitoring or dose modifications. Your doctor may order regular blood tests to monitor kidney function, liver enzymes, and blood sugar control. Tell your doctor about all medications you take, including prescription drugs, over-the-counter products, herbal supplements, and vitamins. Actoplus Met can interact with diuretics, steroids, blood pressure medications, heart failure medications, insulin, and other diabetes drugs, which may increase the risk of low blood sugar or fluid retention. Certain contrast dyes used in imaging procedures may increase the risk of kidney injury and lactic acidosis. Your doctor may temporarily stop metformin before these tests.

Inform your doctor if you are pregnant or planning to become pregnant. While metformin is generally considered safe during pregnancy, pioglitazone is not recommended due to potential effects on fetal development. Actoplus Met is also not recommended during breastfeeding because both medications may pass into breast milk.

Take Actoplus Met exactly as prescribed by your doctor, usually with meals to reduce stomach side effects. Swallow the tablets whole and take them at the same time each day to maintain steady drug levels. Avoid consuming excessive alcohol, as this increases the risk of lactic acidosis with metformin. Do not stop taking the medication suddenly without consulting your doctor, as stopping treatment may lead to uncontrolled blood sugar. Store at room temperature, away from heat and moisture, and keep the medication out of reach of children.

Do I need a prescription to order Actoplus Met?

Yes, a prescription is required from your physician to order Actoplus Met.