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Antabuse Information

Antabuse (Disulfiram) is primarily used as a second-line treatment for chronic alcoholism and alcohol dependence, characterized by an inability to manage or quit drinking despite negative social or physical consequences. It is typically used along with psychotherapeutic and supportive treatments in a motivated individual who has abstained from alcohol for at least 24 hours. Antabuse, which contains the active ingredient disulfiram, belongs to a class of drugs known as aldehyde dehydrogenase inhibitors.

This medication works by disrupting the body’s normal metabolic pathway for ethanol; specifically, it blocks the enzyme that breaks down acetaldehyde, a toxic byproduct of alcohol. So when an individual with alcohol dependence takes alcohol while taking this medication, there is an immediate and severe buildup of acetaldehyde, triggering a violent physical reaction involving flushing, nausea, and palpitations. These reactions serve as a deterrent to drinking alcohol. Antabuse does not actually eliminate the underlying craving for alcohol, nor does it address the neurochemical changes associated with addiction. Instead, it serves as a powerful psychological and physiological deterrent that supports behavioral therapy and long-term sobriety goals.

Antabuse Side Effects

All medications can cause side effects, but the majority are mild and usually short-lived. Some common mild side effects of this medication include headache, weakness, acne or skin rash, stomach upset, impotence in men, metallic or garlic-like aftertaste, and bad breath. Contact your doctor if these mild side effects persist or worsen.

Stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, body itching, body rash, skin blistering, swelling of the face, mouth, tongue, lips, or throat;
• Eye pain or changes in vision;
• Liver problems such as fatigue, malaise, nausea, vomiting, abdominal pain, yellow eyes, and skin;
• Mood changes or abnormal thoughts;
• Nerve problems such as numbness, tingling, pain, or weakness in hands or feet

Inform your doctor about any other side effects you notice that are not listed here.

Antabuse Precautions

Do not take this medication if you are allergic to disulfiram, other ingredients in Antabuse, or any other medicines. Before you start taking this medication, ensure that you inform your doctor about any prior or current medical conditions, including the following:
• Asthma;
• Diabetes;
• Heart disease;
• High blood pressure;
• Kidney disease;
• Liver disease;
• Mental conditions such as mood disorders;
• Seizure disorder;
• Stroke;
• Thyroid problems

Do not use any alcohol or alcohol containing preparations while taking this medication. Using alcohol-based products like hand sanitizers, perfumes, or even inhaling fumes from paint thinners and varnishes can, in some individuals, trigger a reaction. Your doctor may request baseline and periodic blood tests, such as liver function tests, before and during treatment with this medication to ensure it is suitable for you. Continue to schedule regular appointments with your doctor while taking this medicine for active monitoring. Do not use this medicine during pregnancy or while breastfeeding without consulting your doctor.

Disulfiram can enhance the anticoagulant effect of warfarin, potentially leading to bleeding issues. Taking disulfiram with metronidazole can lead to acute psychosis or confusion. Therefore, before using this medication, inform your doctor about any other medications you are currently taking, including herbal medicines and supplements, to determine if it is safe to use along with disulfiram. Take Antabuse tablets once daily, usually in the morning, with or without food, as prescribed by your doctor. If it causes drowsiness, take it at bedtime to minimize its effects. Only use this medicine after at least 24 hours of not drinking alcohol. Avoid alcohol or alcohol containing preparations while using Antabuse and for up to 14 days after stopping it. Consult your doctor and refer to the leaflet included with the medication for additional usage instructions. Store this medication in a cool, dry place, away from moisture and out of reach of children.

Do I need a prescription to order Antabuse?

Yes, a prescription is required from your physician to order Antabuse.