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Bepreve (Bepotastine) Information

Bepreve (bepotastine) is a synthetic, non-sedating antihistamine belonging to the second-generation class, formulated as a 1.5% ophthalmic solution (eye drops). It is indicated for the treatment of ocular itching associated with signs and symptoms of allergic conjunctivitis. Allergic conjunctivitis, often referred to as "pink eye" due to allergies, is a common condition caused by the eyes reacting to allergens like pollen, pet dander, or dust mites. Bepreve is used topically in the eye, typically one drop applied twice daily, to relieve itchiness and irritation.

The mechanism of action for bepotastine involves two primary actions: H1-receptor antagonism and mast cell stabilization. As a potent and selective H1 antagonist, bepotastine blocks the binding of histamine to the H1 receptors located on the conjunctival blood vessels. Histamine is the chemical released by the body in response to an allergen, causing the classic symptoms of allergic itching and swelling. By blocking this receptor, bepotastine stops the histamine from irritating. Additionally, bepotastine is believed to inhibit the release of other inflammatory mediators from mast cells and eosinophils, which are key immune cells in the allergic response. This dual mechanism helps reduce inflammation and provides effective relief from ocular itching.

Bepreve Side Effects

As an ophthalmic solution, Bepreve's side effects are generally localized to the eye and surrounding areas. Common side effects are localized and usually mild, including mild taste disturbance (dysgeusia), which may be noticed immediately after application as the drops drain through the tear ducts into the back of the throat. Other frequent effects are mild irritation at the application site, headache, nasopharyngitis (symptoms of a common cold), and mild eye redness.

However, more serious side effects can occur, although they are rare and often related to allergic or paradoxical reactions. If any of the following symptoms are experienced, the patient should stop using the medication and seek immediate medical attention:
• Hypersensitivity/Allergic Reaction (Ocular or Systemic): Although rare, signs of a severe allergic reaction can include marked swelling of the face, eyelids, or lips, difficulty breathing, or an acute, spreading skin rash.
• Ocular Pain/Vision Changes: Persistent, severe eye pain, vision changes, or worsening eye redness/irritation that does not improve with continued use may indicate a severe reaction or an underlying non-allergic condition.
• Paradoxical Eye Symptoms: In rare cases, the medication may paradoxically worsen the symptoms it is meant to treat, such as severe eye burning, stinging, or inflammation.

Bepreve Precautions

Bepreve (bepotastine ophthalmic solution) is for ophthalmic use only and should not be injected or swallowed. To prevent contamination of the dropper tip and the solution, care must be taken to avoid touching the eyelid, surrounding areas, or any other surface with the dropper tip. Patients who wear contact lenses must be advised to remove their lenses before administering the eye drops. This is because soft contact lenses can absorb the preservative in Bepreve (benzalkonium chloride). Lenses may be reinserted 15 minutes after administration. Bepreve should not be used in patients who have a known history of hypersensitivity to bepotastine or any component of the formulation. Due to the risk of masking a serious condition, patients should be re-evaluated by a healthcare professional if their symptoms worsen or do not improve after a few days of use.

Do I need a prescription to order Bepreve?

Yes, a prescription is required from your physician to order Bepreve.