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Home > Drug Category > Skin Medications (Topical/Oral) > Differin and Equivalent

Differin Information

Differin (adapalene topical) is a retinoid-like compound primarily used to treat acne vulgaris in adults and pediatric patients 12 years of age and older. Acne is a common skin condition characterized by pimples, blackheads, whiteheads, and cysts, resulting from clogged pores, excessive oil production, bacterial infection, and inflammation. Adapalene works by affecting cell growth in the skin, helping to unblock pores and prevent new acne lesions from forming. It normalizes the differentiation of follicular epithelial cells, thereby reducing microcomedone formation (the earliest stage of an acne lesion). This action helps to reduce the number and severity of acne breakouts and promotes faster healing of existing pimples.

Differin Side Effects

The most common side effects of Differin may include dryness, scaling, redness, burning, stinging, itching, or irritation of the skin at the application site, especially during the first few weeks of treatment. These reactions are typically mild to moderate and tend to decrease with continued use. Other possible side effects include skin discomfort, sunburn-like reactions, and peeling. Call your doctor right away if you have any of the serious side effects, such as:
• Allergic reactions (e.g., severe rash, hives, severe itching, swelling of the face, lips, or tongue, difficulty breathing);
• Severe skin irritation, redness, dryness, or peeling that becomes intolerable;
• Significant skin discoloration (e.g., very dark or light patches of skin);
• Worsening of acne, which may be severe or persistent beyond the initial weeks of treatment.

Differin Precautions

Do not use Differin if you are allergic to adapalene or any of its ingredients. Before you start using this medication, tell your doctor about your medical history, including if you have eczema (atopic dermatitis), as it may worsen with adapalene use, or if you have severe sunburn. Avoid using Differin on areas of skin with cuts, abrasions, eczema, or sunburn. Avoid contact with your eyes, lips, nostrils, and mucous membranes. If contact occurs, rinse immediately with warm water. Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. Avoid concurrent use of other topical acne medications that contain alpha hydroxy acids, salicylic acid, sulphur, or resorcinol, as this may increase irritation. Allow some time between applications if these products must be used. Be cautious with abrasive soaps, cleansers, astringents, or products containing alcohol, menthol, or lime, as they can cause additive irritation. Inform your doctor if you are pregnant or planning to become pregnant before using Differin. Differin should not be used during pregnancy due to the potential for fetal harm. If you become pregnant, stop using Differin immediately and contact your doctor. Inform your doctor if you are breastfeeding or planning to breastfeed before using Differin. It is unknown if adapalene passes into breast milk when applied topically. Your doctor will help you decide whether to discontinue breastfeeding or discontinue the medication, considering the importance of the drug to the mother and the potential risk to the infant. Avoid applying Differin to areas where a nursing infant might come into contact with it. Differin is approved for use in pediatric patients 12 years of age and older for the treatment of acne vulgaris.

Use your medicine exactly as prescribed by your doctor. Differin comes as a cream, gel, or lotion. Wash and gently dry the affected area of skin before applying. Apply a thin layer of the medication to the entire affected area of the skin (not just individual pimples), typically once daily in the evening, as directed by your doctor. A pea-sized amount is usually sufficient for the entire face. Do not apply an excessive amount, as this will not speed up results but may increase irritation. Avoid prolonged exposure to sunlight or artificial UV light (such as tanning beds) while using Differin, as it can increase sensitivity to the sun. Use sunscreen and wear protective clothing when outdoors. It may take 8 to 12 weeks to see significant improvement in your acne. It is essential to continue treatment as prescribed, even if you don't see immediate results. Store Differin at room temperature, away from direct sunlight, moisture, and heat. Keep all medicines out of reach of children.

Do I need a prescription to order Differin?

Yes, a prescription is required from your physician to order Differin.