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Home > Drug Category > Skin Medications (Topical/Oral) > Dovonex and Equivalent

Dovonex Information

Dovonex (calcipotriol) is a highly specialized topical medication used for the effective treatment of plaque psoriasis. The active ingredient, calcipotriol, is a synthetic analogue of vitamin D3. Unlike traditional corticosteroids, Dovonex does not primarily function as an anti-inflammatory agent. Instead, it works by directly targeting the underlying cellular processes of psoriasis, which are characterized by the excessive and rapid growth of skin cells. Calcipotriol helps to regulate skin cell production and differentiation, slowing down the abnormal proliferation of these cells and promoting their proper maturation. By normalizing this cellular process, Dovonex helps to reduce the thickness and scaling of psoriatic plaques. Its unique mechanism of action makes it a valuable alternative or a complementary therapy to corticosteroids. Dovonex is available in several formulations, including cream, ointment, and a solution for the scalp, which allows for precise and convenient application to different affected areas of the body.

Dovonex Side Effects

The most common side effects associated with Dovonex are typically confined to the application site and are generally mild. Patients may experience a sensation of skin irritation, itching, erythema (redness), or dryness, as well as folliculitis (inflammation of the hair follicles). These effects are usually temporary and may diminish with continued use as the skin acclimates to the medication. However, it is crucial to be aware of the more serious side effects that can occur, particularly with excessive or prolonged use. You should contact your doctor immediately if you experience any of the serious side effects listed below:

• Hypercalcemia: The excessive and prolonged use of calcipotriol, particularly when applied to large body surface areas or at doses exceeding the recommended maximum, can lead to hypercalcemia, characterized by an elevated blood calcium level. Symptoms of this condition may include nausea, vomiting, constipation, muscle weakness, and confusion. This profound side effect highlights the importance of adhering to the prescribed dosage and application instructions.

• Hypersensitivity reactions: Severe allergic reactions are a possibility, though they are rare. Symptoms may include a widespread rash, hives, or swelling of the face, lips, or tongue. If you experience any of these signs, discontinue use and seek emergency medical attention.

• Worsening of psoriasis: While Dovonex is intended to treat psoriasis, some patients may, in rare cases, experience a paradoxical worsening of their condition or a "rebound effect" upon discontinuation of the medication.

• Photosensitivity: There have been reports of an increased sensitivity to sunlight (photosensitivity) in patients using Dovonex. It is advisable to take precautions, such as using sunscreen and protective clothing, to minimize excessive exposure to both natural and artificial sunlight while taking this medication.

Dovonex Precautions

To ensure the safe and effective use of Dovonex, it is essential to follow all precautions. You should not use this medication if you have a known allergy to calcipotriol or any of the product's other ingredients. Dovonex is not intended for use on skin conditions other than psoriasis. It is for external use only. It is imperative to avoid contact with the eyes, face, and genital areas, as they can be irritated. Dovonex should not be used in patients with known disorders of calcium metabolism. To minimize the risk of hypercalcemia, it is crucial not to exceed the recommended weekly dose and to avoid applying the medication to more than 30% of your body surface area. Talk to your doctor before using this medication in children.

You must inform your doctor about all the medications you are currently taking, including prescription drugs, over-the-counter products, and any herbal supplements. While there are no known significant drug interactions with topical Dovonex, caution should be exercised when using other topical vitamin D analogues, as this could increase the risk of systemic effects.

If you are pregnant or planning to become pregnant, you should discuss the use of Dovonex with your doctor. It is classified as Pregnancy Category C, and there are no adequate and well-controlled studies in pregnant women. Therefore, it should be used during pregnancy only if the potential benefits outweigh the possible risks to the fetus. Additionally, inform your doctor if you are breastfeeding. It is not known whether topical calcipotriol would result in sufficient systemic absorption to produce detectable quantities in human milk.

Do I need a prescription to order Dovonex?

Yes, a prescription is required from your physician to order Dovonex.