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Endometrin Information

Endometrin (progesterone) Vaginal Insert is used to support embryo implantation and early pregnancy by supplementing corpus luteal function in infertile women as part of an Assisted Reproductive Technology (ART) treatment program. Progesterone is a hormone vital for preparing the lining of the uterus (endometrium) to receive and nourish an embryo, transforming it into a secretory state necessary for successful implantation and maintenance of early pregnancy. This leads to an optimal uterine environment for the developing embryo. Endometrin is used in individuals undergoing ART who need to supplement their natural progesterone levels. Progesterone supplements like Endometrin deliver the hormone in a form that the body can utilize directly in the uterus. Once inside the body, the progesterone is released and helps the uterus prepare for and sustain a pregnancy.

Endometrin Side Effects

The most common side effects of Endometrin may include headache, abdominal distension, abdominal pain, constipation, breast tenderness, fatigue, mood swings, dizziness, flatulence, nausea, vulvovaginal disorders (such as discomfort, burning sensation, discharge, dryness, and bleeding), and uterine cramping. Call your doctor right away if you have any of the serious side effects, such as:
• Bloody diarrhea
• Breast lumps
• Chest pain
• Heart attack symptoms, such as chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating
• Liver problems, such as nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes)
• Signs of an allergic reaction (anaphylaxis), such as rash, breathing difficulties, itching or swelling of the face, tongue, or throat
• Signs of a stroke, such as sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with speech or balance, sudden trouble seeing in one or both eyes
• Signs of a thromboembolic event (e.g., blood clot), such as severe pain in your calves or chest, sudden shortness of breath, coughing up blood, sudden blindness, pain, swelling, warmth, or redness in one or both legs
• Unusual vaginal bleeding that is not part of your menstrual cycle
• Worsening depression or unusual changes in mood or behaviour

Endometrin Precautions

Do not use Endometrin if you are allergic to progesterone or other ingredients in this medication. Before you start using this medication, tell your doctor about your medical history, including if you have undiagnosed vaginal bleeding, known missed abortion or ectopic pregnancy, liver disease, known or suspected breast cancer or cancer of the genital organs, active arterial or venous thromboembolism or a history of blood clots (e.g., stroke, heart attack, deep venous thrombosis, pulmonary embolism), porphyria disorder, seizures or epilepsy, migraine headaches, asthma, diabetes, heart or kidney disease, a history of depression, think you may be pregnant, or plan to become pregnant, are breastfeeding, or are planning to breastfeed. Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be a drug interaction between Endometrin and other medications, including drugs affecting liver enzymes. The use of other vaginal products (such as antifungal products) is not recommended with Endometrin, as this may alter progesterone release and absorption. Inform your doctor if you are pregnant or planning to become pregnant before using Endometrin. Endometrin is specifically indicated to support embryo implantation and early pregnancy in ART programs and is generally used during the first trimester and discontinued around 10-12 weeks gestation. A pregnant woman should discuss her specific pregnancy needs with a doctor. Inform your doctor if you are breastfeeding or planning to breastfeed before using Endometrin. It is unknown if progesterone passes into breast milk or if it may harm a nursing infant, and breastfeeding is generally not recommended while using this medication. Do not use this medicine in children without talking to your doctor. The safety and effectiveness of Endometrin in children have not been established.

Use your medicine exactly as prescribed by your doctor. Endometrin comes as a vaginal insert. Wash and dry your hands thoroughly. Unwrap the applicator and place one tablet into the space at the end of the applicator. The tablet should fit snugly. Insert the applicator gently into your vagina while standing, sitting, or lying down with your knees bent, and press the plunger to release the insert. Remove and discard the applicator after each use. Do not crush, chew, or break it. The usual dose is 100 mg administered vaginally two or three times daily, starting the day after oocyte retrieval and continuing for up to 10 weeks of total duration (or 12 weeks of gestation), as directed by your healthcare provider. Take Endometrin at the same time(s) each day to help you remember. Your doctor may order regular tests to monitor your pregnancy and adjust your dosage as needed. Continue taking Endometrin as directed by your doctor. Do not stop using this medicine suddenly or lower the dosage without consulting your doctor, as sudden discontinuation may lead to increased anxiety, moodiness, and increased sensitivity to seizures. Store Endometrin at room temperature, away from moisture and heat. Keep all medicines out of reach of children.

Do I need a prescription to order Endometrin?

Yes, a prescription is required from your physician to order Endometrin.