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Entresto Information

Entresto (Sacubitril/Valsartan) is primarily used to treat chronic heart failure in adults. It is used to reduce the risk of hospitalization and sudden cardiac death. It is typically prescribed for adults and children 1 year and above with a reduced ejection fraction. Entresto is a unique medication in that it is the first in a class of drugs known as an angiotensin receptor-neprilysin Inhibitor. It contains two active ingredients: sacubitril and valsartan.

Valsartan is an angiotensin receptor blocker that works by blocking the receptor for angiotensin II, which effectively relaxes the blood vessels and reduces the heart's workload. Sacubitril is a neprilysin inhibitor. Neprilysin is an enzyme that breaks down natriuretic peptides, which are substances that promote vasodilation (widening of blood vessels) and help the kidneys excrete excess sodium and fluid. By inhibiting neprilysin, sacubitril essentially boosts the levels of these protective peptides, providing a counter-regulatory force to the stress of heart failure.

This dual approach is superior to first-line medications like ACE inhibitors alone in reducing the risk of cardiovascular death and hospitalizations related to chronic and severe heart failure.

Entresto Side Effects

As with any medication, Entresto can cause a range of side effects, some of which are more common and others that are serious but rare. Some common side effects of this medication include dizziness, itchiness, nausea, rash, spinning sensation, tiredness, and weakness.

Stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, body itching, body rash, skin blistering, swelling of the face, mouth, tongue, lips, or throat;
• High blood potassium with symptoms like irregular heartbeat, muscle weakness, and generally feeling unwell;
• Kidney problems such as decreased urination, nausea, vomiting, swelling of the feet and ankles;
• Severe low pressure with symptoms like severe dizziness and fainting

Inform your doctor about any other side effects you notice that are not listed here.

Entresto Precautions

Do not use this medication if you are allergic to sacubitril and valsartan, other ingredients in Entresto, or any other medicines. Before you start taking this medication, ensure that you inform your doctor about any prior or current medical conditions, including the following:
• Angioedema;
• Dehydration;
• Diabetes;
• High blood potassium;
• Kidney disease;
• Liver disease;
• Low blood pressure

Before you drive a vehicle, use tools or operate machines, or carry out other activities that require concentration, make sure you know how Entresto affects you. If you feel dizzy or exhausted while taking this medicine, do not drive, cycle, or use any tools or machines. Valsartan may cause severe harm to an unborn fetus and should not be used during pregnancy. If you become pregnant while taking this medication, stop taking it immediately and call your doctor. It is imperative to use an effective contraceptive while taking this medication and for 1 week after the last dose. Breastfeeding is not recommended while using this medication due to potential adverse effects in the breastfed infant. The safety and efficacy of this medication have not been established in children younger than 1 year.

Using this medication with some other medications, such as ACE inhibitors, can lead to severe adverse effects. Therefore, it is essential to inform your healthcare provider about all the medicines, including herbal medications, that you are taking before using Entresto to prevent potential drug interactions. Take Entresto tablets orally with or without food. Your doctor will determine and adjust your dose based on your condition. Take this medication regularly as prescribed for optimal effectiveness. Check out the leaflets in the medication pack for more usage instructions. Store this medication at room temperature, away from sunlight and moisture, and out of children's reach.

Do I need a prescription to order Entresto?

Yes, a prescription is required from your physician to order Entresto.