Farxiga (Dapagliflozin) Information
Farxiga, which contains the active ingredient dapagliflozin, is a medication used to help control blood sugar levels in adults with type 2 diabetes. It is also used to lower the risk of kidney disease getting worse, reduce hospital stays for heart failure, and decrease the risk of heart-related death in people with chronic kidney disease or heart failure. Farxiga works by helping the kidneys remove excess sugar from the body through the urine, lowering blood sugar and easing strain on both the kidneys and the heart. It is taken by mouth once daily, making it convenient for long-term treatment.
The mechanism of action of dapagliflozin involves blocking SGLT-2 transporters in the kidneys. These transporters normally reabsorb sugar back into the bloodstream. When they are blocked, more sugar is excreted in the urine, lowering blood sugar levels. This process also reduces pressure inside the kidneys and helps remove excess fluid, contributing to kidney protection and heart benefits. Taking Farxiga consistently each day helps maintain these effects on blood sugar, kidney health, and heart function.
Farxiga Side Effects
Farxiga is generally well-tolerated, but some common side effects may occur. Commonly reported effects include increased urination, thirst, mild dehydration, and a higher risk of genital yeast infections due to increased urinary glucose. Some people experience urinary tract infections, nasal or throat irritation, or back pain. A slight decrease in blood pressure may occur, especially when starting therapy.
More serious side effects can occur and require immediate medical attention. Stop taking the medication and seek help if you experience:
• Allergic reactions, including swelling of the face, tongue, or throat, difficulty breathing, rash
• Pain or swelling in the genital area with fever
• Severe urinary tract infection, including fever, flank pain, chills, and burning urination
• Signs of diabetic ketoacidosis, including nausea, vomiting, stomach pain, or rapid breathing
• Signs of severe dehydration, including dizziness, fainting, and rapid heartbeat
• Worsening kidney function
Farxiga Precautions
Do not use Farxiga if you are allergic to dapagliflozin or any ingredient in the drug. It should not be used in people with severe kidney impairment or those on dialysis. Before starting treatment, tell your doctor about your complete medical history. Individuals with chronic urinary infections, dehydration, low blood pressure, type 1 diabetes, a history of ketoacidosis, liver disease, or adherence to very low-carbohydrate diets may require special monitoring or adjustments. Your doctor may recommend blood tests to monitor kidney function and blood sugar levels during treatment.
Tell your doctor about all medications you take, including prescription medicines, over-the-counter products, herbal supplements, and vitamins. Farxiga can interact with diuretics (water pills), insulin or other diabetes medicines, NSAIDs, blood pressure medications, and lithium. Avoid excessive alcohol because it can increase the risk of dehydration and ketoacidosis.
Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Farxiga is not recommended during the second and third trimesters because it may affect the developing kidneys of the fetus. It is also generally avoided during breastfeeding because it may enter breast milk.
Take Farxiga exactly as prescribed by your doctor, usually once daily with or without food. Swallow the tablet whole and try to take it at the same time each day. Drink enough fluids to stay well hydrated, especially in hot weather or during physical activity. Do not stop taking the medication suddenly without consulting your doctor, as this may worsen your blood sugar control or underlying heart or kidney condition. Store at room temperature away from moisture and heat, and keep the tablets out of reach of children.
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