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Grazax Information

Grazax (Standardized Allergen Extract, Timothy Grass Pollen) is a prescription sublingual (under-the-tongue) tablet used for allergen-specific immunotherapy. It is specifically designed to treat grass pollen-induced allergic rhinitis, with or without conjunctivitis (also known as hay fever). This medication is indicated for adults and children aged 5 years and older who have been diagnosed with a grass pollen allergy confirmed by skin prick and/or specific IgE tests.

Unlike conventional allergy medications that only manage symptoms, Grazax addresses the underlying cause of the allergy. The tablet contains a standardized amount of allergen extract from Timothy grass pollen. By administering a small, controlled dose of the allergen daily, the treatment works by gradually exposing the immune system to the pollen. This process, known as immunotherapy, helps to build up an immunological tolerance to the allergen, thereby reducing the body's over-reactive response to grass pollen over time. The ultimate goal is to lessen the severity of allergic symptoms and reduce the need for symptomatic relief medications like antihistamines and nasal sprays.

For best results, Grazax should be taken once daily. The tablet is placed under the tongue, where it dissolves within seconds. It is essential not to swallow the tablet for at least one minute and to avoid eating or drinking for at least five minutes afterward, as food and beverages can interfere with the medication's absorption. The treatment is a long-term therapy, typically initiated several months before the grass pollen season and continued throughout the season for at least three consecutive years to achieve a sustained clinical effect.

Grazax Side Effects

The most common side effects of Grazax are generally localized and mild to moderate in severity, occurring in the mouth and throat. These are expected reactions as the body begins to build tolerance to the allergen. The most frequently reported side effects include oral pruritus (itching of the mouth), a tingling sensation under the tongue, and irritation or swelling of the mouth, tongue, or throat. Itching of the ears, sneezing, and a runny nose may also occur. Gastrointestinal side effects like stomach pain, nausea, or dyspepsia can also occur. These local reactions are typically most pronounced during the first week of treatment and tend to subside over time.

However, serious and potentially life-threatening side effects, though rare, can occur. If you experience any of the following, you should stop taking the medication and seek immediate medical attention:

• Severe Systemic Allergic Reactions (Anaphylaxis): There is a risk of a severe, life-threatening allergic reaction, including anaphylaxis. Symptoms may include difficulty breathing, tightness or swelling of the throat, difficulty swallowing, dizziness, or fainting.

• Asthma Exacerbation: Grazax can cause or worsen asthma symptoms. Patients with severe, unstable, or uncontrolled asthma should not take this medication. If you have asthma and experience worsening symptoms like wheezing or shortness of breath, you must contact your doctor immediately.

• Other Serious Reactions: Other less common but serious side effects can include severe stomach cramps, vomiting, diarrhea, or symptoms of eosinophilic esophagitis, such as persistent heartburn or difficulty swallowing.

Grazax Precautions

Due to the risk of severe allergic reactions, the first dose of Grazax must be taken under the supervision of a healthcare professional in a clinical setting. Patients should be monitored for at least 30 minutes after the first dose to ensure they do not have a severe reaction. Your doctor may also prescribe an auto-injectable epinephrine pen for you to keep on hand and will provide instructions on how to use it in case of a severe reaction.

You should not take Grazax if you have severe or uncontrolled asthma, a history of a severe allergic reaction to allergen immunotherapy, or any inflammation, sores, or ulcers in your mouth. You should also temporarily stop the treatment if you undergo oral surgery, such as a tooth extraction, or have a severe oral infection, and wait until the area has fully healed.

It is crucial to inform your doctor about all of your medical conditions, especially if you have a history of heart disease, an autoimmune disease, or a condition that affects your immune system. You should also tell your doctor about all medications you are taking, including over-the-counter drugs, as some, like beta-blockers, may interfere with the emergency treatment for a severe allergic reaction. Do not take a double dose if you miss a dose.

If you are pregnant or breastfeeding, you should consult your doctor. Treatment with Grazax should not be initiated during pregnancy and is not recommended for use in pregnant or breastfeeding women. If you become pregnant while on the medication, your doctor will need to evaluate whether it is safe to continue. The safety and effectiveness of Grazax in children under 5 years of age and adults over 65 years of age have not been established.

Do I need a prescription to order Grazax?

Yes, a prescription is required from your physician to order Grazax.