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Home > Drug Category > Diabetic Medications and Products > Invokamet and Equivalent

Invokamet Information

Invokamet (Canagliflozin/Metformin) is used to control blood sugar levels in adults with type 2 diabetes mellitus whose blood sugar has not been controlled despite the use of either canagliflozin or metformin or other types of anti-diabetic medications. It is typically used along with healthy dietary and lifestyle modifications to manage type 2 diabetes mellitus. Also, Invokamet is used to reduce the risk of major cardiovascular events and the progression of kidney disease in specific adult populations with type 2 diabetes. Type 2 diabetes is a chronic condition where the body either doesn't produce enough insulin or doesn't use insulin effectively, leading to high blood sugar levels. If left uncontrolled, high blood sugar can lead to serious health complications like heart disease, kidney damage, nerve damage, and blindness. Invokamet is a combination drug that contains two active ingredients: canagliflozin and metformin. Canagliflozin belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors, while metformin is a biguanide. These two active ingredients work through different mechanisms to help lower blood sugar. Canagliflozin works in the kidneys by blocking the reabsorption of glucose back into the bloodstream. It achieves this by blocking the action of sodium-glucose cotransporter 2, a protein responsible for the reabsorption of most glucose. This action leads to increased glucose excretion in the urine, thereby reducing blood glucose levels. Metformin, on the other hand, primarily works by decreasing glucose production in the liver and improving the body's sensitivity to insulin, allowing the cells to take up and utilize glucose more efficiently from the blood. By combining these two distinct mechanisms, Invokamet provides a comprehensive approach to managing type 2 diabetes.

Invokamet Side Effects

Like all medications, this medication may cause some side effects. Some common side effects include nausea, vomiting, abdominal discomfort, diarrhea, bloating, increased urination, unusual dry mouth, or weakness. Stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, hives, swelling of the face, lips, or throat;
• Dehydration with symptoms such as severe dizziness and lightheadedness, peeing less than usual;
• Diabetic ketoacidosis - with symptoms such as abdominal pain, severe nausea and vomiting, fruity breath smell;
• Kidney or urinary tract infections– frequent urination, dark or bloody pee, fever, and chills;
• Lactic acidosis with symptoms such as muscle pain, drowsiness, breathing difficulties;
• Low blood sugar with symptoms such as palpitations, excessive sweating, headache, anxiety and fainting;
• Necrotizing Fasciitis with symptoms such as pain, redness, tenderness, or swelling of the perineum and genitals, fever, and malaise;
• Vitamin B12 Deficiency, which may lead to a low red blood cell count

Inform your doctor about any other side effects you notice that are not listed here.

Invokamet Precautions

Do not use this medicine if you are allergic to canagliflozin, metformin, or any other ingredients in Invokamet. Before using this medication, ensure you inform your doctor about any medical conditions you previously or currently have, including the following:
• Bone problems such as osteoporosis;
• Dehydration;
• Electrolyte imbalance, such as high levels of potassium in the blood;
• Heart disease;
• High cholesterol levels in the blood;
• Kidney disease;
• Liver disease;
• Low blood pressure;
• Stroke;
• Urinary tract infection;
• Vitamin B12 deficiency

This medication is not for use in individuals with type 1 diabetes or a diabetic complication called diabetic ketoacidosis. There is an increased risk of amputation of your lower limbs in individuals with specific heart disease who take this medication. Therefore, ensure good foot care and contact your doctor if you notice any infected wounds or leg ulcers. This drug may cause dizziness and drowsiness; hence, it is recommended that you do not drive or operate machinery until you are sure how it affects you. Avoid smoking, alcohol, or alcoholic beverages while taking this medication, as these substances can cause you to develop side effects. Regular monitoring of blood sugar levels and other relevant parameters is crucial while taking Invokamet. If you are scheduled for surgery or any medical procedure, such as an X-ray examination, CT scan, or other method that requires the use of a dye, inform your healthcare provider that you are taking Invokamet. Do not use this medication during pregnancy or while breastfeeding unless it is deemed beneficial by your doctor. If you get pregnant while taking this medication, inform your doctor immediately.

This medication should be used with caution in older adults (>65 yrs) as they may be more sensitive to its side effects. The active ingredients in this medication may interact with other medications or substances, such as diuretics, digoxin, phenytoin, rifampin, and ritonavir. Therefore, inform your healthcare provider about all the medicines, including herbal supplements and over-the-counter medications, that you are taking before starting Invokamet to prevent potential drug interactions. Take the Invokamet tablets orally as prescribed by your doctor. Do not crush, chew, or break the tablet unless your doctor instructs you to do so. Use this medication regularly for optimal blood sugar control. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do I need a prescription to order Invokamet?

Yes, a prescription is required from your physician to order Invokamet.