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Home > Drug Category > Diabetic Medications and Products > Kazano and Equivalent

Kazano Information

Kazano (Alogliptin/Metformin) is used in conjunction with a healthy diet and lifestyle modifications to control blood sugar in individuals living with type 2 diabetes mellitus. It is typically used in individuals who do not achieve adequate glucose control with diet, exercise, and metformin or alogliptin alone. Type 2 diabetes is a chronic condition where the body either doesn't produce enough insulin or doesn't use insulin effectively, leading to elevated blood sugar (glucose) levels. Managing blood sugar levels in type 2 diabetes is essential to prevent long-term complications such as heart disease, kidney failure, nerve damage, and vision loss. The active ingredients in Kazano are alogliptin and metformin. Alogliptin belongs to the drug class of Dipeptidyl Peptidase-4 (DPP-4) inhibitors, while metformin is a biguanide. Alogliptin inhibits the DPP-4 enzyme, which usually breaks down incretin hormones (like GLP-1 and GIP). By preventing this breakdown, alogliptin increases the levels of active incretin in the body. These incretins stimulate the pancreas to release more insulin when blood sugar levels are high and reduce the amount of sugar produced by the liver, thereby lowering blood glucose. Metformin, in turn, reduces glucose production by the liver, decreases the absorption of glucose from the gut, and enhances the body's sensitivity to insulin, helping cells absorb more glucose from the bloodstream.

Kazano Side Effects

Like all medications, this oral medicine may cause some side effects. Some common side effects include bloating, constipation, headache, dry and itchy skin, joint or muscle pain, nausea, a metallic taste in the mouth, and sore throat. Stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, hives, swelling of the face, lips, or throat;
• Anemia (low red blood cells) with symptoms including dizziness, pale skin, unusual tiredness;
• Decreased thyroid function with symptoms including weight gain, feeling cold, fatigue;
• Flu-like symptoms such as sudden lack of energy, fever, cough, sore throat;
• Gallstones with symptoms including sudden stomach pain, often after meals;
• Kidney failure with symptoms including decreased urine production, body swelling, fatigue;
• Lactic acidosis with symptoms such as muscle pain, drowsiness, and breathing difficulties;
• Liver problems with symptoms including nausea, vomiting, yellow eyes, and skin;
• Low blood sugar with symptoms such as palpitations, excessive sweating, headache, anxiety, and fainting;
• Pancreatitis with symptoms such as abdominal pain on the upper left side, back pain, nausea;
• Peripheral neuropathy with symptoms such as numbness and prickling spreading up the legs and arms;
• Skin rash and blisters

Inform your doctor about any other side effects you notice that are not listed here.

Kazano Precautions

Do not use this medicine if you are allergic to alogliptin, metformin, or any other ingredients in Kazano. Before using this medication, ensure you inform your doctor about any medical conditions you previously or currently have, including the following:
• Anemia;
• Dehydration;
• Heart disease, such as heart failure;
• Kidney disease;
• Liver disease;
• Low blood pressure;
• Pancreatitis;
• Thyroid disease, such as hypothyroidism;
• Vitamin B12 deficiency

This medication is not for individuals with Type 1 diabetes or those experiencing diabetic ketoacidosis (a serious diabetic complication). Be aware of the signs of low blood sugar (hypoglycemia), which include anxiety, sweating, hunger, and a pounding heart. Contact your doctor immediately if you experience these symptoms. Alcohol should be avoided while taking this medication, as it can increase the risk of adverse effects. This drug may cause dizziness and drowsiness. Until you know how it affects you, do not drive or operate heavy machinery. Do not use this medication if you are pregnant or breastfeeding. If you are scheduled for surgery or any radiological procedure that involves dye, please inform your healthcare provider that you are taking this medication. This medication is not suitable for individuals under 18 years of age.

Older adults should use this medication with caution, as they may be more susceptible to its side effects. The active ingredients in this medication may interact with other drugs or substances, such as acetazolamide, angiotensin-converting enzyme inhibitors (e.g., enalapril, ramipril), beta-adrenergic blockers (e.g., atenolol, metoprolol), corticosteroids, dolutegravir, leuprolide, and ranolazine. Therefore, inform your healthcare provider about all the medicines, including herbal supplements and over-the-counter medications, that you are taking before starting Kazano to prevent potential drug interactions. Take Kazano tablets orally, twice daily, with food, to reduce the risk of gastrointestinal side effects associated with metformin. Swallow the tablets whole with water. It is essential to use this medication regularly as prescribed and to continue with a balanced diet and regular exercise as part of your overall diabetes management plan. Store this medication at room temperature and keep it out of the reach of children.

Do I need a prescription to order Kazano?

Yes, a prescription is required from your physician to order Kazano.