0

Home > Drug Category > Hepatitis Medications > Mavyret and Equivalent

Mavyret Information

Mavyret (Glecaprevir/Pibrentasvir) is used for the treatment of acute or chronic hepatitis C virus (HCV) infection in adults and children 3 years and older, including those with compensated liver cirrhosis. It is used for all major genotypes of Hepatitis C, including genotypes 1 to 6. Hepatitis C is a viral liver infection that spreads primarily through blood-to-blood contact, often through unsafe injections, blood transfusions, or needle sharing. If left untreated, it can progress to liver fibrosis, cirrhosis, hepatocellular carcinoma, and ultimately liver failure. The active ingredients are glecaprevir and pibrentasvir, which classify it as a direct-acting antiviral medication. This combination drug works by targeting specific proteins that the virus needs to replicate. Glecaprevir inhibits the NS3/4A protease, and pibrentasvir targets the NS5A protein. By blocking these two different, essential viral proteins, Mavyret stops the hepatitis C virus from making copies of itself and infecting new cells, ultimately helping the body clear the infection. This dual approach is highly effective and is a key reason for its high cure rates across all six major HCV genotypes.

Mavyret Side Effects

Some mild side effects of this medicine include diarrhea, headache, itchiness, nausea, and tiredness. Contact your doctor if these common side effects persist or worsen. Stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, hives, swelling of the face, mouth, tongue, lips, or throat;
• Liver damage with symptoms such as vomiting, nausea, yellow eyes and skin, change in color of stool and urine, and body weakness

Inform your doctor about any other side effects you notice that are not listed here.

Mavyret Precautions

Do not use this medicine if you are allergic to the active and inactive ingredients in Mavyret or any other medicine. Before using this medication, ensure you inform your doctor about any medical conditions you previously or currently have, including the following:
• Diabetes;
• Hepatitis B;
• History of kidney or liver transplant;
• Severely reduced liver function

Before starting treatment with Mavyret, your doctor will do blood tests to check for hepatitis B infection, as taking this medication can lead to Hepatitis B virus reactivation. Consult your doctor before taking this medication during pregnancy or while breastfeeding. Mavyret may interact with other medicines like atazanavir, atorvastatin, dabigatran, ethinyl estradiol, rifampin, and simvastatin. Tell your doctor about all the medications, including herbal supplements, you are taking before using Mavyret to minimize the risk of interactions.

Take Mavyret tablets by mouth as three tablets once daily with food as directed by your doctor. You must swallow the tablets whole and not chew or crush them. The typical treatment course for most individuals lasts eight weeks. Your doctor will determine the appropriate treatment course for you. Do not skip any dose or take more than the prescribed daily dose. You should always finish the entire course of treatment to ensure you clear the virus completely. Check out the leaflet in the medication pack for more usage instructions. Store this medication in its original container at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do I need a prescription to order Mavyret?

Yes, a prescription is required from your physician to order Mavyret.