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Maxitrol Eye (Neomycin/polymyxin B/dexamethasone) Information

Maxitrol Eye is a prescription ophthalmic (eye) medication that combines two antibiotics (neomycin and polymyxin B) and a corticosteroid (dexamethasone) to treat steroid-responsive inflammatory eye conditions where a bacterial infection exists or is a risk. It is commonly used for conditions such as uveitis and chemical or thermal radiation burns. Do not use Maxitrol Eye if you have an active viral eye infection, such as Herpes Simplex (dendritic keratitis). It is available as an ointment and suspension. The ointment is often used at bedtime to provide long-lasting contact with the eye while you sleep. The suspension or drops are used for daytime application, as they are easier to apply and cause less vision blurring.

The mechanism of action involves killing or preventing the growth of various types of bacteria by disrupting their cell membranes and protein synthesis. Neomycin inhibits protein synthesis (30S ribosome) while Polymyxin B disrupts the cell membrane. The dexamethasone component is a powerful steroid that suppresses the body's inflammatory response, reducing swelling, redness, and itching.

Maxitrol Eye Side Effects

Maxitrol Eye is generally well-tolerated, but common side effects may occur as your body adjusts to the medication. Commonly reported effects include temporary blurred vision, stinging or burning upon application, and increased tearing or watery eyes.

More serious side effects can occur and require immediate medical attention. Stop taking the medication and seek help if you experience:
• Cataract Formation: Prolonged use is a known risk factor for developing posterior subcapsular cataracts.
• Delayed Healing: After surgeries like cataract removal, steroids can slow the rate of eye healing.
• Increased Eye Pressure: Long-term use of steroids can lead to glaucoma or damage to the optic nerve.
• Secondary Infections: Steroids can mask or worsen fungal or viral eye infections (such as Herpes Simplex).
• Severe Allergic Reactions: Swelling of the face or eyelids, severe itching, or difficulty breathing.

Maxitrol Eye Precautions

Do not use Maxitrol Eye if you have a known allergy to neomycin, polymyxin B, dexamethasone, or any of the inactive ingredients in the medication. Neomycin sensitivity can cause contact dermatitis. Before starting treatment, inform your doctor of your complete medical history, especially if you have a history of viral, fungal, or mycobacterial eye infections or glaucoma. Tell your doctor about all medications you are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Maxitrol Eye may interact with other drugs, especially other steroid eye drops. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Maxitrol should only be used in pregnancy if the benefits outweigh the risks. It is unknown if the components of Maxitrol pass into breast milk.

Use Maxitrol Eye exactly as your doctor tells you. For the suspension, shake the bottle well before use. Instill one to two drops into the conjunctival sac. For the ointment, apply a small ribbon (about 1/2 inch) into the lower eyelid. Do not touch the tip of the dropper or tube to your eye or any other surface to prevent infection. Do not wear contact lenses during treatment for eye infections. If you must wear them, wait at least 15 minutes after using the drops before reinserting. Do not use Maxitrol Eye for more than 10 days without a pressure check. Prolonged use of neomycin can lead to skin sensitization or fungal overgrowth. Store at room temperature away from light. Do not freeze. Discard any remaining medication after the treatment period ends.

Do I need a prescription to order Maxitrol Eye?

Yes, a prescription is required from your physician to order Maxitrol Eye.