Mezavant Information
Mezavant (Mesalamine) is primarily used to induce and maintain remission in people with mild-to-moderate ulcerative colitis, a chronic inflammatory bowel disease where the immune system attacks the lining of the large intestine and rectum. This condition typically causes painful sores, swelling, and symptoms like bloody diarrhea or urgent cramping. It may also be used to treat and prevent acute flare-ups in individuals with Crohn's disease, another inflammatory bowel disease similar to ulcerative colitis, but which can affect any part of the gastrointestinal tract.
The active ingredient in Mezavant is mesalamine, a member of the class of drugs known as aminosalicylates. It is believed to act topically by coming into direct contact with the inflamed gut wall to inhibit the production of pro-inflammatory mediators such as prostaglandins and leukotrienes. This action suppresses local gut inflammation, thereby promoting intestinal lining repair, while preventing the inflammatory symptoms associated with these conditions from recurring during maintenance therapy. Unlike some other brands of mesalamine, Mezavant uses a specialized Multi-Matrix System that delays the release of the medication until it reaches the colon, thereby reducing systemic side effects.
Mezavant Side Effects
While this medication is generally well-tolerated, it can cause some notable side effects. Common side effects include abdominal pain, diarrhea, nausea, vomiting, headache, joint and muscle pain, and indigestion. Contact your doctor if these mild side effects persist or worsen.
Stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, body itching, body rash, skin blistering, swelling of the face, mouth, tongue, lips, or throat;
• Acute intolerance syndrome with symptoms like worsening abdominal or stomach cramps or pain, bloody diarrhea, chills, and fever;
• Easy bruising or bleeding;
• Inflamed heart with symptoms like chest pain, fever, or trouble breathing;
• Kidney problems such as such as a change in the colour or amount of urine produced and swollen limbs, or sudden flank pain;
• Low red blood cells with symptoms like dizziness, pale skin, unusual tiredness or weakness;
• Pancreatitis with symptoms such as abdominal pain on the upper left side, back pain, nausea, and fever
Inform your doctor about any other side effects you notice that are not listed here.
Mezavant Precautions
Do not take this medication if you are allergic to aspirin, mesalamine, other ingredients in Mezavant, or any other medicines. Before you start taking this medication, ensure that you inform your doctor about any prior or current medical conditions, including the following:
• Active viral or bacterial infection;
• Blood count disorders, such as low white blood cells;
• Breathing problems such as asthma and chronic obstructive pulmonary disease;
• Gastrointestinal issues such as a blocked intestine or slow emptying;
• Heart disease;
• Kidney disease;
• Liver problems;
• Pancreas problems
Some individuals have experienced worsening Crohn's or ulcerative colitis symptoms while taking mesalamine, indicating a possible acute intolerance to mesalamine. Watch out for sudden cramping, bad belly pain, bloody diarrhea, headache, rash, and maybe fever. Contact your doctor if you notice these symptoms. This medication may cause a decrease in sperm production for men. If this is a concern, consult your physician. Mesalamine has been shown to cross the placenta and enter breast milk. Therefore, it should not be used during pregnancy or while breastfeeding unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately. This medication is not recommended for use in children.
Mezavant can make your skin much more sensitive to the sun. This is particularly true if you have existing skin conditions like eczema or atopic dermatitis. Therefore, use sunscreen and wear protective clothing when outdoors while taking this medication. Taking Mezavant with other medications that affect the kidneys or stomach (like Ibuprofen or certain blood thinners) can increase the risk of side effects. Therefore, before using this medication, inform your doctor about any other medications you are currently taking, including herbal medicines and supplements, to determine if it is safe to use along with Mezavant.
Mezavant tablets should be taken orally and swallowed whole without breaking the outer coating. Your doctor will determine the appropriate dosage of this medication for you depending on your condition. It is essential to use this medication regularly as your doctor prescribes to achieve optimal control of your symptoms. Store all forms of this medication at room temperature, protect them from light and moisture, and keep them out of the reach of children.
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