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Home > Drug Category > Parkinson's Disease, Dopamine Agonists > Mirapex and Equivalent

Why Buy Mirapex or Generic Pramipexole from BigMountainDrugs.com?

Buy Mirapex or generic pramipexole online from BigMountainDrugs.com with secure prescription processing, competitive pricing, and discreet home delivery. Serving customers since 2007 with an average 4.9-star customer rating, we make ordering quick and easy. Choose the option that matches your prescription and budget, then submit your order in just a few minutes. A valid prescription is required.

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Ready to order? Visit our How to Order page for step-by-step instructions or browse our FAQ for more information about prescriptions and shipping.

What Dosage Strengths Are Available for Mirapex and Generic Pramipexole?

Mirapex and generic pramipexole immediate release are available in the following strengths:
• 0.125 mg
• 0.25 mg
• 0.5 mg
• 1 mg
• 1.5 mg

Your healthcare provider will determine the appropriate dose for your needs. Order the strength prescribed by your healthcare provider.

What is Mirapex (Pramipexole) Used For?

Mirapex (pramipexole) is a non-ergot dopamine agonist primarily used to manage the motor symptoms of Parkinson’s disease, a progressive neurological disorder primarily caused by the death of nerve cells in the brain's substantia nigra, leading to a critical deficiency of the neurotransmitter dopamine. It is also used either alone in early stages of this condition or alongside levodopa in advanced stages. Mirapex may also be used to treat moderate to severe restless legs syndrome, a neurological disorder linked to abnormal dopamine signaling in brain pathways that control movement and limb sensations.

This medication works by acting as a substitute for dopamine in the brain. Normally, nerve cells release dopamine to bind to receiving sites called dopamine receptors, which send signals that control smooth body movements and regulate motor pathways. In conditions like Parkinson's disease, the loss of dopamine-producing cells leaves these receptors unstimulated, resulting in stiffness, tremors, and slow movement. In Restless Legs Syndrome, dopamine signaling pathways become unstable, causing abnormal nerve impulses in the limbs, especially at night.

Because pramipexole has a chemical structure that mimics dopamine, it directly attaches to and activates these same dopamine receptors in the brain's movement and reward centers. It activates these receptors directly and bypasses the need for natural dopamine production, restoring the chemical signals needed for proper movement and coordination and stabilizing improper nerve signaling to ease involuntary urges to move.

Always take pramipexole exactly as prescribed by your healthcare provider. For complete safety information, view the full prescribing information.

What Side Effects Can Mirapex or Generic Pramipexole Cause?

Like all medications, pramipexole does have a range of possible side effects. Some common side effects of this medication include abnormal dreams, constipation, dizziness, drowsiness, dry mouth, headache, hiccups, insomnia, loss of appetite, nausea, tiredness, and vomiting. Contact your doctor if these mild side effects persist or worsen.

Serious side effects may include:
• Falling asleep suddenly (Sleep Attacks);
• Impulse control disorders such as pathological gambling, compulsive shopping;
• Neurological or mental disorders with symptoms like hallucinations, compulsive behaviors, confusion, uncontrolled movements of the body, depression, nervousness, and seizures;
• Severe hypotension with symptoms like dizziness, nausea, fainting; • Uncontrolled sudden movements (dyskinesia);
• Withdrawal symptoms such as depression, anxiety, fatigue, sweating, panic attacks, trouble sleeping;

Consult your doctor as soon as possible if you notice any of these serious side effects. Also, seek immediate medical attention if you notice signs of an allergic reaction, such as breathing difficulties, body rash, itching, hives, skin blistering, or swelling of the face, lips, or throat. Inform your doctor about any other side effects you notice that are not listed here.

Warnings

Do not take this medication if you have an allergic reaction to pramipexole, or any other ingredients in Mirapex. Also, before you start taking this medication, ensure that you inform your doctor about any prior or current medical conditions, including the following:
• Heart disease;
• High blood pressure;
• Kidney disease;
• Liver disease;
• Low blood pressure;
• Lung problems;
• Mental disorders such as depression, psychosis, suicidal ideation;
• Peptic ulcers or gastrointestinal bleeding;
• Skin disease such as melanoma;

Some medications that block dopamine receptors, such as antipsychotics like haloperidol, risperidone, or antiemetics like metoclopramide, can directly oppose pramipexole's action and drastically reduce its effectiveness. Therefore, before using this medication, inform your doctor about any other medications you are currently taking, including herbal medicines and supplements, to determine if it is safe to use along with Mirapex. Never stop using this medication suddenly. Abruptly stopping Mirapex can cause a serious reaction resembling neuroleptic malignant syndrome, with symptoms like fever, confusion, and severe muscle stiffness. This medication must always be tapered off gradually under your doctor's supervision if you wish to discontinue it.

Because pramipexole can cause individuals taking it to fall asleep suddenly without feeling drowsy first, it is highly advised that you should not drive, operate heavy machinery, or participate in other high-risk activities until you and your doctor are sure how the medication affects your level of alertness. Dopamine agonist therapy can trigger intense, uncharacteristic urges that some individuals struggle to control. These include compulsive gambling, hypersexuality, binge eating, and uncontrollable spending. Inform your doctor if you or those around you observe unusual urges or cravings that lead to behaviors you typically wouldn't engage in.

For people with Parkinson's, there's a possible link between the disease and an increased risk of melanoma. However, it's not yet clear if this is due to Parkinson's disease or the medications used to treat it. Therefore, it's important to schedule regular skin checkups with your doctor. There are not enough data on the safety of using this medication in pregnant or breastfeeding women. Therefore, consult your doctor before using this medication during pregnancy or while breastfeeding to assess its risks and benefits. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do I need a prescription to order Mirapex?

Yes, a prescription is required from your physician to order Mirapex.