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Omnaris Information

Omnaris (ciclesonide) is an intranasal corticosteroid (glucocorticoid) used to treat symptoms of seasonal and perennial allergic rhinitis. It effectively reduces inflammation in the nasal passages, providing relief from a variety of allergy symptoms, including nasal congestion, sneezing, a runny nose, and an itchy nose. Unlike some older corticosteroids, ciclesonide is a prodrug, which means it is inactive when first administered. Once it reaches the nasal mucosa, it is converted by intracellular enzymes into its active metabolite, des-ciclesonide. This targeted activation helps to maximize its therapeutic effect while minimizing the potential for systemic side effects.

Ciclesonide is a potent anti-inflammatory agent that works by binding to glucocorticoid receptors in the cells of the nasal lining. This action prevents the release of inflammatory mediators and other substances that contribute to the allergic cascade. By inhibiting the action of these inflammatory cells and chemicals, Omnaris significantly reduces the swelling and irritation that cause nasal allergy symptoms. This specific mechanism of action makes it highly effective, particularly for nasal congestion, which can be a stubborn symptom to treat.

Omnaris is designed for once-daily use, providing 24-hour relief. For optimal efficacy, it is crucial to use the product consistently every day, rather than on an as-needed basis. While some symptom improvement may be noticeable within 24 to 48 hours, the full therapeutic effect is typically achieved after several days of continuous use. It is available in Canada as a prescription-only medication for adults and children 6 years of age and older. The standard dose for adults and adolescents 12 years and older is two sprays per nostril, once daily. For children aged 6 to 11, the dose is one spray per nostril, once daily. The dose may be reduced to one spray per nostril once daily, once symptoms are under control. The pump must be primed before the first use and after any period of non-use to ensure a full dose is delivered.

Omnaris Side Effects

While Omnaris is generally well-tolerated, it can cause some side effects, which are usually mild and localized to the nasal area. The most common side effects reported include nosebleeds, nasal discomfort, and headache. Other common side effects may include a sore throat or a cough. These effects are often temporary and may improve with continued use.

However, more serious side effects can occur, although they are rare. If you experience any of the following, you should stop using the medication and consult a healthcare professional immediately:

• Serious Nasal and Respiratory Effects: Prolonged or high-dose use of corticosteroids can lead to more serious issues. This includes the potential for nasal septum perforation (a hole in the wall between the nostrils), which may manifest as a whistling sound in the nose. There is also a risk of localized infections in the nose and throat, such as Candida albicans (yeast) infection, which may require medical treatment. You should also be cautious of severe or frequent nosebleeds.

• Systemic Corticosteroid Effects: Although the systemic absorption of Omnaris is minimal, using it at higher-than-recommended doses or for prolonged periods can lead to systemic corticosteroid effects. This can result in hypercorticism, which is an excess of cortisol in the body, and adrenal suppression, where the body’s natural production of cortisol is reduced. Symptoms may include fatigue, dizziness, and nausea.

• Vision-Related Effects: In rare cases, long-term use of intranasal corticosteroids has been associated with the development of cataracts and glaucoma, particularly in individuals with a history of these conditions. Any changes in vision or eye pain should be reported to a doctor immediately.

• Hypersensitivity Reactions: Though rare, a severe allergic reaction to Omnaris is possible. Symptoms of a severe allergic reaction may include a rash, hives, swelling of the face, lips, or tongue, and difficulty breathing.

Omnaris Precautions

Before using Omnaris, it is essential to have a thorough discussion with your doctor or pharmacist about your medical history and any other medications you are taking. Omnaris is not recommended for children under 6 years of age. You should also inform your healthcare provider if you have any pre-existing medical conditions, including recent nasal trauma, ulcers, or surgery that has not yet healed, as corticosteroids can inhibit wound healing. Individuals with eye conditions such as cataracts, glaucoma, or ocular herpes simplex should use this product with caution and under medical supervision. It is also important to disclose any untreated fungal, bacterial, or viral infections, as corticosteroids can potentially worsen these conditions. This is particularly important for individuals who have had or have been exposed to chickenpox, measles, or tuberculosis, as the immunosuppressing effects of corticosteroids can make these infections more serious. The recommended daily dosage should not be exceeded. If your symptoms do not improve after a few weeks of daily use, consult your doctor. It is also important to note that the growth rate of some children may be slowed while using this product. If your child requires long-term use, their doctor should monitor their growth. For pregnant or breastfeeding individuals, it is essential to consult a healthcare professional before using Omnaris. While the systemic absorption is minimal, the potential risks and benefits should be weighed. The product should be stored at room temperature and kept out of reach of children.

Do I need a prescription to order Omnaris?

Yes, a prescription is required from your physician to order Omnaris.