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Home > Drug Category > Disorders of the Digestive Tract (IBS,Crohns Disease,Stomach) > Salazopyrin and Equivalent

Salazopyrin (Sulfasalazine) Information

Salazopyrin, which contains the active ingredient sulfasalazine, is an oral medication used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease, as well as rheumatoid arthritis. It helps control inflammation, reduce pain, and manage flare-ups by calming the immune system and preventing further tissue damage. Salazopyrin is taken orally, usually as tablets, and may be used both to treat active disease and to maintain remission.

The mechanism of action of sulfasalazine involves reducing inflammation in the gut and joints. In the intestines, it is broken down into active components that locally suppress inflammatory chemicals such as prostaglandins and leukotrienes, which drive tissue irritation. It also modulates immune system activity, helping prevent the overactive immune responses that contribute to bowel inflammation or joint damage. Its dual anti-inflammatory and immunomodulatory effects make it effective in controlling both gut and joint symptoms.

Salazopyrin Side Effects

Salazopyrin is generally well-tolerated, but some common side effects may occur. Commonly reported effects include headaches, nausea, vomiting, loss of appetite, or mild stomach discomfort. Some people notice diarrhea, bloating, a mild rash, or orange-yellow discoloration of the urine or skin. Temporary fatigue or mild dizziness can also occur, especially when starting treatment.

More serious side effects can occur and require immediate medical attention. Stop taking the medication and seek help if you experience:
• Severe allergic reactions, including rash, itching, swelling of the face, lips, or throat, difficulty breathing
• Severe stomach pain, vomiting blood, or black/tarry stools
• Signs of blood disorders, including unexplained bruising, bleeding, fever, sore throat, or persistent fatigue
• Signs of liver problems, including yellowing of the skin or eyes, dark urine, persistent nausea or vomiting
• Unusual swelling or joint pain worsening despite treatment

Salazopyrin Precautions

Do not use Salazopyrin if you are allergic to sulfasalazine, sulfonamides, or salicylates. Before starting treatment, inform your doctor of your complete medical history, especially if you have liver or kidney problems, blood disorders, G6PD deficiency, asthma, or a history of allergies. Regular blood and urine tests may be advised to monitor for potential side effects. Tell your doctor about all medications you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Salazopyrin may interact with blood thinners, certain diabetes medications, methotrexate, and other drugs that affect the liver or kidneys.

Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Salazopyrin should only be used during pregnancy if clearly needed. In men, Salazopyrin may temporarily reduce sperm count. This effect is usually reversed once the medication is stopped. Discuss this with your doctor if you are planning to father a child. The medicine passes into breast milk in small amounts. Your doctor will monitor your infant for side effects.

Take Salazopyrin exactly as prescribed, usually one to four times daily, depending on your condition and the prescribed regimen. Swallow tablets whole with plenty of water, preferably after meals, to reduce stomach upset. Do not stop the medication abruptly without consulting your doctor, as symptoms may return. This medication may turn your urine or skin orange-yellow. It can also permanently stain soft contact lenses. Avoid wearing soft contact lenses while taking Salazopyrin. Salazopyrin can make your skin more sensitive to sunlight. Wear protective clothing and use a high-SPF sunscreen when outdoors. Store at room temperature, away from moisture and heat, and keep out of reach of children.

Do I need a prescription to order Salazopyrin?

Yes, a prescription is required from your physician to order Salazopyrin.