Salofalk Suppositories (Mesalamine/5-aminosalicylic acid) Information
Salofalk Suppositories, which contain the active ingredient mesalamine (5-aminosalicylic acid), are a medication used to treat ulcerative proctitis and distal ulcerative colitis, which are types of inflammation in the rectum and lower colon. They help relieve symptoms such as rectal bleeding, urgency, a feeling of incomplete bowel evacuation, and abdominal discomfort. These suppositories deliver medication directly to the affected area, helping control inflammation where it is most needed.
The mechanism of action of mesalazine involves reducing inflammation in the rectal lining. It blocks chemicals that cause inflammation, such as prostaglandins and leukotrienes, and reduces oxidative stress in the tissues. Because it acts locally, it helps heal the affected area while minimizing side effects elsewhere in the body. The suppository stays in contact with the rectal tissue for an extended period, increasing its effectiveness.
Salofalk Suppositories Side Effects
Salofalk Suppositories are generally well tolerated, but common side effects may occur. Commonly reported effects include slight rectal irritation, burning, or discomfort after inserting the suppository. Some people experience mild headaches, nausea, stomach upset, diarrhea, abdominal cramps, bloating, or increased gas. These effects are usually temporary and may improve as your body adjusts to the medication.
More serious side effects can occur and require immediate medical attention. Stop taking the medication and seek help if you experience:
• Severe abdominal pain, persistent diarrhea, or worsening rectal bleeding
• Signs of kidney problems, including reduced urine output, swelling, and unexplained fatigue
• Signs of liver problems, including yellowing of the skin or eyes, dark urine, persistent nausea or vomiting
• Severe allergic reactions, including rash, itching, swelling of the face, lips, or throat, difficulty breathing
• Signs of possible blood disorders, including unexplained fever, sore throat, or unusual bruising
Salofalk Suppositories Precautions
Do not use Salofalk Suppositories if you are allergic to mesalamine, salicylates or any ingredient in the medication. Before starting treatment, tell your doctor about your complete medical history, especially if you have kidney or liver problems or a history of blood disorders. Regular monitoring may be recommended to ensure safety.
Inform your doctor about all medications you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Salofalk may interact with blood thinners, NSAIDs, corticosteroids, or medications affecting kidney function.
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Salofalk is generally considered low risk during pregnancy if clearly needed. Mesalazine passes into breast milk in small amounts, so infants should be monitored for possible side effects.
Use Salofalk suppositories exactly as prescribed. Wash your hands before and after use. For best results, empty your bowels before inserting the suppository. Insert the suppository into the rectum once daily at bedtime and retain it all night (for at least 1 to 3 hours) to allow prolonged contact with the tissue. Avoid straining and stay lying down for a few minutes after insertion to prevent expulsion. Do not stop treatment without consulting your doctor, as symptoms may return. Store the suppositories at room temperature, away from heat and moisture, and keep them out of reach of children.
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