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Clofranil SR 75 mg from India

The generic Clomipramine SR 75 mg tablets come from India also called Clofranil SR by Sun Pharma. It is available in the quantity of 100 tablets.

Anafranil (Clomipramine) Information

Anafranil (clomipramine hydrochloride) is a prescription medication that belongs to the class of tricyclic antidepressants (TCAs). While initially developed as an antidepressant, its primary use in clinical practice is for the treatment of Obsessive-Compulsive Disorder (OCD) in adults and children. It is highly effective at reducing the severity of obsessive thoughts and compulsive behaviors. Anafranil may also be prescribed off-label for other conditions, including panic disorder, specific phobias, and chronic pain. However, its unique pharmacological profile makes it a primary choice for complex and treatment-resistant OCD cases.

The mechanism of action for clomipramine involves a potent effect on multiple neurotransmitter systems in the brain. It is considered the most selective serotonin reuptake inhibitor (SRI) among all TCAs. It strongly inhibits the reuptake of serotonin (5-HT) into nerve cells, increasing the concentration of 5-HT in the synaptic cleft, which is believed to be the main factor in its anti-OCD effects. Clomipramine also inhibits the reuptake of norepinephrine (NE), though less potently. As a traditional TCA, it also blocks histamine, alpha1-adrenergic, and muscarinic acetylcholine receptors, which contribute significantly to its prominent side effect profile, including sedation and anticholinergic effects.

Anafranil is available in Canada as capsules and is approved for use in adults and children (typically 10 years of age and older) for OCD. However, its use in younger patients requires specialist supervision. Dosing must be titrated slowly (gradually increased) over several weeks to minimize the risk of serious side effects. Due to its significant sedating effects, the total daily dose is often taken at bedtime. Unlike some newer antidepressants, a complete therapeutic response may take several weeks or even months of consistent use to be fully realized.

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Do I need a prescription to order Clomipramine 75 mg ?

Yes, a prescription is required from your physician to order Clomipramine 75 mg.