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Best Price on Generic Chloroquine Phosphate 250 mg from India

The generic Aralen 250 mg comes from India known as Lariago by Ipca. It is available in the quantity of 100 tablets.

Aralen (Chloroquine) Information

Aralen (chloroquine) is a 4-aminoquinoline derivative used primarily as an antimalarial and historically as an anti-inflammatory agent. It is the first-line and highly effective treatment for malaria caused by chloroquine-sensitive strains of Plasmodium species, including P. falciparum, P. vivax, P. ovale, and P. malariae. Chloroquine is a blood schizonticide, meaning it acts rapidly to kill the asexual parasites circulating in the red blood cells, which are responsible for the acute, symptomatic stage of the disease. While replaced mainly in inflammatory conditions by its analog, hydroxychloroquine (Plaquenil), chloroquine was historically used to treat rheumatoid arthritis and lupus erythematosus. Chloroquine is generally well-absorbed orally and has a long terminal half-life, allowing for once-weekly prophylactic dosing. Prophylaxis typically begins 1 to 2 weeks before exposure and continues for 4 weeks after leaving the endemic area.

The mechanism of action for chloroquine primarily involves its concentration within the acidic food vacuole of the intraerythrocytic malaria parasite. The parasite degrades the host hemoglobin to obtain amino acids for survival, which releases the toxic heme molecule. The parasite polymerizes, typically, this poisonous heme into non-toxic hemozoin. Chloroquine interferes with this process by binding to the heme, preventing its polymerization. The resulting accumulation of free, toxic heme oxidizes the parasite's membranes, leading to cell lysis and death. The drug is less effective against the dormant liver stages (hypnozoites) of P. vivax and P. ovale (requiring co-administration with primaquine for radical cure). It only kills the gametocytes (sexual stages) of P. vivax, P. ovale, and P. malariae, but not P. falciparum.

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Do I need a prescription to order Chloroquine Phosphate 250 mg ?

Yes, a prescription is required from your physician to order Chloroquine Phosphate 250 mg.