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Hydrochlorothiazide HCTZ 25mg from Canada

Generic Hydrodiuril 25 mg comes from Canada. It is available in the quantity of 100 tablets.

Hydrodiuril (Hydrochlorothiazide) Information

Hydrodiuril, which contains the active ingredient hydrochlorothiazide (HCT), is a widely used diuretic medication classified as a thiazide diuretic. It is a cornerstone drug in the pharmacological management of hypertension (high blood pressure), often prescribed as a monotherapy or in combination with other antihypertensive agents, such as beta-blockers, ACE inhibitors, or Angiotensin II Receptor Blockers (ARBs). Beyond its primary role in blood pressure control, HCT is also effectively used to manage edema (fluid retention) associated with various underlying medical conditions. These conditions include congestive heart failure (CHF), hepatic cirrhosis, treatment with corticosteroids and estrogens, and certain types of renal dysfunction, particularly nephrotic syndrome. Hydrochlorothiazide is an orally administered medication available in various strengths. It is typically taken once daily, usually in the morning, to align the diuretic peak with daytime hours and thereby minimize the inconvenience of nocturnal urination. Its relatively long duration of action supports its once-daily dosing regimen.

The intricate mechanism of action for hydrochlorothiazide is localized to the distal convoluted tubules of the kidney, a specific segment of the nephron responsible for fine-tuning electrolyte balance. HCT works by inhibiting the Sodium-Chloride (Na/Cl) co-transporter system on the luminal membrane of tubular cells. By effectively blocking the reabsorption of both sodium and chloride ions from the tubular fluid back into the bloodstream, HCT significantly increases the amount of sodium, chloride, and consequently, water, that is excreted in the urine. This action leads to a mild to moderate diuretic effect and a corresponding reduction in plasma and extracellular fluid volume. This reduction in volume contributes to the initial drop in blood pressure. Over a more extended therapeutic period, HCT also exerts a distinct antihypertensive effect through a mechanism involving direct vasodilation (widening of blood vessels). However, the exact cellular mechanism remains unclear. This dual action—volume reduction and vasodilation—sustains the long-term antihypertensive efficacy. Unlike many diuretics, HCT paradoxically decreases calcium excretion while simultaneously increasing uric acid reabsorption. The drug is not significantly metabolized in the body and is primarily excreted unchanged by the kidneys.

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Do I need a prescription to order Hydrochlorothiazide 25 mg ?

Yes, a prescription is required from your physician to order Hydrochlorothiazide 25 mg.