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Save on Generic Parnate 10 mg from Canada

The generic Tranylcypromine 10 mg comes from Canada. It is available in the quantity of 100, 200, and 300 tablets.

Parnate (Tranylcypromine) Information

Parnate (tranylcypromine sulphate) is a prescription medication classified as a non-selective, irreversible Monoamine Oxidase Inhibitor (MAOI). It is reserved for the treatment of Refractory Major Depressive Disorder (MDD)—severe depression that has not responded adequately to other classes of antidepressants, such as SSRIs, SNRIs, or TCAs. Parnate is one of the most potent and effective antidepressants available. However, its use requires meticulous patient adherence to strict dietary and medication restrictions due to its severe interaction risks. It is considered a specialized treatment, managed primarily by psychiatrists with expertise in MAOI therapy.

The mechanism of action for tranylcypromine is based on its potent and irreversible inhibition of monoamine oxidase enzymes. It irreversibly inhibits both MAO-A and MAO-B. The MAO-A enzyme metabolizes norepinephrine (NE) and serotonin (5-HT), and the MAO-B enzyme primarily metabolizes dopamine (DA) and phenylethylamine (PEA). By non-selectively blocking both forms of the enzyme, tranylcypromine dramatically increases the concentration and activity of all three major monoamine neurotransmitters (NE, 5-HT, and DA) in the brain. This robust increase in monoamine levels provides its powerful antidepressant effect. Because the inhibition is permanent, the body must synthesize new MAO enzymes for the drug's effect to subside, which takes approximately 10 to 14 days; this long duration necessitates the use of a 14-day washout period when switching medications.

Parnate is available in Canada as a prescription-only tablet for use in adults 18 years of age and older. Dosing is highly individualized and must be initiated at a low dose (e.g., 10 mg/day) and slowly titrated up, typically in divided doses throughout the day, up to a maximum of 60 mg/day. Due to its stimulating and activating properties, the final dose of the day is often taken no later than mid-afternoon to prevent treatment-emergent insomnia.

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Do I need a prescription to order Tranylcypromine 10 mg ?

Yes, a prescription is required from your physician to order Tranylcypromine 10 mg.