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Save on Generic Zavesca 100 mg from Canada

The generic Miglustat 100 mg comes from Canada. It is available in the quantity of 90 capsules.

Zavesca Information

Zavesca (Miglustat) is primarily used in treating Type 1 Gaucher disease. In this condition, the body lacks an enzyme required to degrade a specific lipid (glucosylceramide), resulting in its accumulation in the liver, spleen, and bones. Zavesca is typically used for adults with mild-to-moderate symptoms who cannot tolerate enzyme replacement therapy, the standard treatment, perhaps due to an allergy or difficulty accessing veins for IV infusions. It is, however, not recommended for individuals with severe symptoms of type 1 Gaucher disease. It may also be used to treat Niemann-Pick type C, a severe neurological disease characterized by the accumulation of lipids in the brain and other organs. Because Zavesca is a small-molecule drug, it can cross the blood-brain barrier, a significant advantage for treating neurological symptoms.

The active ingredient, miglustat, is a synthetic analogue of D-glucose and belongs to a class of drugs known as substrate-reduction therapy. It acts as a competitive, reversible inhibitor of the enzyme glucosylceramide synthase, which catalyzes the first step in glycosphingolipid synthesis. By inhibiting the production of these excess fats at the source, miglustat reduces the metabolic load to a level that the patient’s residual natural enzymes can realistically manage. This appears to stabilize organ size and improve blood counts, while its ability to cross the blood-brain barrier likely accounts for its unique role in slowing the neurological decline associated with Niemann-Pick Type C.

Miglustat has also been found effective in the treatment of Pompe disease, a genetic disorder in which the body can’t produce enough of the enzyme acid alpha-glucosidase. It is used exclusively in combination with the enzyme replacement therapy Pombiliti for adults with late-onset Pompe disease. In Pompe disease, miglustat acts as a pharmacological chaperone that binds to and stabilizes the infused replacement enzyme, thereby preventing its degradation during circulation. This structural support ensures that a higher concentration of functional enzyme reaches muscle cells, where it can release and degrade the toxic accumulation of glycogen.

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Do I need a prescription to order Miglustat 100 mg ?

Yes, a prescription is required from your physician to order Miglustat 100 mg.