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Brand Galliprant 20 mg from Canada by Elanco

The brand Galliprant 20 mg comes from Canada manufactured by Elanco. It is available in the quantity of 30 tablets.

What is Galliprant (Grapiprant) Used For?

Galliprant (Grapiprant) is a prescription non-steroidal, non-cyclooxygenase inhibiting anti-inflammatory medication used for the treatment of pain and other symptoms of inflammation associated with mild to moderate osteoarthritis in dogs.

Its active ingredient, grapiprant, works by selectively blocking the EP4 receptor, which is a major receptor for a substance called prostaglandin E2. Prostaglandin E2 is the main substance responsible for causing pain and inflammation in dogs with osteoarthritis. When prostaglandin E2 binds to the EP4 receptor, it triggers several physical effects such as the widening of blood vessels and the production of more inflammatory mediators. Importantly, this receptor is the primary way that prostaglandin E2 makes sensory neurons more sensitive, which leads directly to the perception of pain. By specifically blocking this receptor, grapiprant prevents these signals from being activated, thereby reducing both pain and inflammation.

Older nonsteroidal anti-inflammatory drugs (like carprofen or meloxicam) work by blocking the COX enzymes that produce prostaglandin E2 in the first place. However, while this is effective in curtailing the pain and inflammation associated with prostaglandin E2, it does affect the beneficial effects of prostaglandin E2, such as protecting the stomach lining and maintaining healthy blood flow to the kidneys. This is ultimately why long-term use of these older nonsteroidal anti-inflammatory drugs carries a risk of stomach irritation and kidney strain. This risk is less associated with grapiprant due to its different approach.

Always administer grapiprant to your dog exactly as prescribed by your veterinarian. For more information on its use, check out its full product monograph.

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Do I need a prescription to order Galliprant 20 mg ?

Yes, a prescription is required from your physician to order Galliprant 20 mg.