Canasa Suppositories Information
Canasa Suppositories (Mesalamine/5-aminosalicylic acid) are used topically to treat active ulcerative colitis, a localized form of inflammatory bowel disease affecting the large intestine, characterized by inflammation, ulcers, diarrhea, and bleeding. It is typically used when this condition affects the distal portion of the large intestine, such as the sigmoid colon and rectum. Its active ingredient, mesalamine (5-aminosalicylic acid, 5-ASA), belongs to the aminosalicylate class of drugs.
It works as a topical anti-inflammatory agent, acting directly on the rectal mucosa rather than through systemic absorption. By blocking the production of inflammatory mediators, it effectively relieves the inflamed tissues. In ulcerative colitis, in which the immune system inappropriately attacks the gut lining, Canasa Suppositories help by reducing inflammation and promoting mucosal healing. This targeted action alleviates hallmark symptoms such as frequent bowel movements and bloody stools. Because it is administered directly into the rectum, it delivers a high concentration of medicine exactly where the disease is most active, providing relief with fewer systemic side effects than oral steroids.
Canasa Suppositories Side Effects
Most people tend to tolerate Canasa Suppositories quite well, but like any medication that interacts with the immune system, it can cause various adverse effects. Some mild side effects of this medication may include abdominal discomfort, acne, back pain, constipation, diarrhea, bloating, dizziness, ear or throat pain, fatigue, hair loss, headache, increased sensitivity of the skin to sunlight, irritation of the rectal area, muscle or joint pain, nausea, tiredness, tremor, and vomiting. Contact your physician immediately if any of these temporary side effects last or worsen.
Stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, body itching, body rash, skin blistering, swelling of the face, mouth, tongue, lips, or throat;
• Acute intolerance syndrome that includes cramps, sharp abdominal (stomach area) pain, bloody diarrhea, and sometimes fever;
• Flat red rash or blisters on your skin, mouth, nose, and genitals;
• Inflamed heart with symptoms like chest pain, fever, or trouble breathing;
• Kidney problems with symptoms like blood in urine, painful urination, increased need to urinate, back or groin pain
Inform your doctor about any other side effects you notice that are not listed here.
Canasa Suppositories Precautions
Do not use this medication if you are allergic to mesalamine, aspirin, other ingredients in Canasa Suppositories, or any other medicines. Before you start taking this medication, ensure that you inform your doctor about any prior or current medical conditions, including the following:
• Active viral or bacterial infection;
• Bleeding or clotting disorder;
• Blood count disorders, such as low white blood cells;
• Breathing problems such as asthma or chronic obstructive pulmonary disease;
• Diseases causing slow stomach emptying, like pyloric stenosis;
• Heart disease, such as pericarditis;
• Kidney disease;
• Liver disease;
• Pancreas disease
Your body can react adversely to Canasa Suppositories by mimicking a flare-up of inflammatory bowel disease. However, this is a rare occurrence and can be confusing to depict. If your condition worsens suddenly after starting this topical medication, you may have an intolerance and should seek medical attention right away. Mesalamine can increase your skin’s sensitivity to the sun, so it is advised to limit your skin’s exposure to sunlight and wear extra sunscreen or protective clothing when outdoors. Check with your doctor regularly if you are using this medication for extended periods, as your doctor needs to perform some routine lab tests to monitor the effects of this medication on your body.
Do not use this medication during pregnancy or while breastfeeding unless recommended by your doctor after careful evaluation of its risks and benefits. Canasa Suppositories are not recommended for use in children, as their safety and efficacy have not been established in this age group. Taking mesalamine with immunosuppressants such as azathioprine can cause bone marrow suppression, thereby increasing the risk of serious infections. Therefore, it is essential to discuss with your doctor any medications you are currently taking, including herbal medicines or supplements, to determine if they can interact with mesalamine.
Canasa Suppositories are available in different dosage strengths and should be inserted into the rectum as directed in the medication pack. Consult your physician for the appropriate dose, as it usually depends on the medical condition being treated, among other factors. The generally recommended adult dose is one suppository twice daily for 3-6 weeks. The suppository should be left inside for at least one to three hours for optimal effect. Consult the medication leaflet for more details about the use of this medication. Store this medication at room temperature away from sunlight, humidity, and pets.
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