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Home > Drug Category > Pet Medication > Credelio Plus and Equivalent

Credelio Plus Information

Credelio Plus (Lotilaner/Milbemycin Oxime) is used to treat adult fleas in dogs and puppies at least 8 weeks old and weighing a minimum of 4.4 lbs (1.4 kg). The drug is used to control flea and tick infestations. Flea infestations can cause symptoms such as excessive scratching, red bumps, hair loss, and flea dirt on the fur. Tick infestations include symptoms such as inflammation, lethargy, appetite loss, and visible ticks attached to the skin. Isoxazoline insecticides like Lotilaner and antihelmintics like Milbemycin Oxime interfere with the parasite’s nervous system, causing their paralysis and death.

Credelio Plus Side Effects

The most common side effects of Credelio Plus may include appetite loss, diarrhea, hyperactivity, lethargy, and vomiting. Call your veterinarian right away if your dog has any of the serious side effects, such as:
• Signs of neurologic adverse reaction, including tremors, ataxia, and seizures

Credelio Plus Precautions

Do not use Credelio Plus if your dog is allergic to Lotilaner, Milbemycin Oxime, or other ingredients in this medication. Before you start administering this medication, tell your veterinarian about your dog’s medical history, including if it has a history of neurological disorders, a history of seizures, p-glycoprotein deficiency with MDR or ABCB1-1 delta gene mutation, lactating, pregnancy, or breeding. Tell your veterinarian about all your dog’s medications, including prescription, OTC, herbal supplements, and vitamins. There may be a drug interaction between Credelio Plus and other medications. Do not administer Credelio Plus if your dog is pregnant, breeding, or lactating. It is unknown if this drug will have negative effects on pregnant, breeding, or lactating dogs. Do not give this drug to children. Administer this medicine exactly as prescribed by your veterinarian. Credelio Plus comes as a chewable tablet. Give your dog a full dose. Ensure your dog consumes the complete dose. Credelio Plus may not effectively prevent all heartworm strains. Test all dogs older than 6 months for existing heartworm infection before starting treatment with Credelio Plus. This medicine is only for dogs at least 8 weeks old and weighing at least 4.4 lbs (1.4 kg). Do not give this medicine to your pet repeatedly. Administering this drug when your vet does not prescribe it can lead to parasite resistance to the drug. Administer this drug only in dogs. Please do not use it for cats. Please do not take it. It is not for human use. Wash your hands immediately after administering Credelio Plus. Store Credelio Plus at room temperature, away from moisture and heat. Keep all medicines out of reach of children.

Do I need a prescription to order Credelio Plus?

Yes, a prescription is required from your physician to order Credelio Plus.