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Durezol (Difluprednate) Information

Durezol (difluprednate) is a potent corticosteroid formulated as an ophthalmic emulsion (eye drop). It is indicated for the treatment of inflammation and pain associated with ocular surgery, particularly following cataract surgery, and for endogenous anterior uveitis, a serious inflammatory condition of the middle layer of the eye. Due to its high potency, it can effectively reduce significant inflammation that can interfere with healing and cause discomfort. Durezol is dosed as one drop in the affected eye(s) up to 4 times daily, or as directed by a doctor, depending on the condition being treated.

The mechanism of action for difluprednate is potent anti-inflammatory and immunosuppressive. As a synthetic corticosteroid, difluprednate works by penetrating cell membranes and binding to specific glucocorticoid receptors within the cell cytoplasm. This complex then enters the nucleus, where it modulates the expression of genes involved in the inflammatory response. Crucially, it inhibits the release of inflammatory mediators, such as prostaglandins and leukotrienes, by blocking phospholipase A2 activity. This cascade effect stabilizes cellular and lysosomal membranes, constricts blood vessels, and suppresses the migration of white blood cells (leukocytes) to the injury site, thereby reducing swelling, redness, and pain. Difluprednate is a highly potent steroid, and its emulsion formulation ensures excellent penetration into the eye's anterior chamber.

Durezol Side Effects

As a potent ophthalmic steroid, Durezol's side effects are primarily ocular. They are often associated with their high potency and long treatment duration. Common side effects are localized, mild, and include temporary irritation, stinging, or burning upon application. Other frequent effects are ocular hyperemia (eye redness) and minor eye pain or discomfort.

However, more serious side effects can occur, particularly with prolonged use, requiring careful patient monitoring. If any of the following symptoms are experienced, the patient should stop using the drops and seek immediate medical attention:

• Delayed Wound Healing: Steroids may inhibit corneal wound healing, which is a critical factor after ocular surgery or injury.

• Elevated Intraocular Pressure (IOP) / Glaucoma: The most serious common adverse effect of prolonged steroid use is a significant and sustained increase in pressure within the eye, which can lead to optic nerve damage and vision loss if not managed. IOP must be monitored during treatment.

• Posterior Subcapsular Cataracts: Prolonged use of ophthalmic corticosteroids is associated with the development of cataracts, particularly in children and patients with underlying conditions, leading to lens clouding and impaired vision.

• Secondary Ocular Infections: Steroids suppress the eye's immune response, making the eye more susceptible to secondary infections from fungi, viruses (especially Herpes simplex), or bacteria. Steroids can exacerbate existing, undiagnosed infections.

Durezol Precautions

Durezol (difluprednate) is for ophthalmic use only and must not be injected or swallowed. The bottle must be shaken gently before use. Due to the significant risk of elevated Intraocular Pressure (IOP) and glaucoma, patients using Durezol must have their IOP measured frequently by an eye care professional, especially during extended treatment periods. The drug is contraindicated in patients with most viral diseases of the cornea and conjunctiva, especially active Herpes simplex keratitis, as the steroid can rapidly worsen the infection. It is also contraindicated in mycobacterial or fungal ocular infections. To prevent contamination, the dropper tip must not come into contact with any surface. Because this formulation contains a preservative, contact lenses should generally not be worn during treatment. Suppose signs and symptoms fail to improve after 2 days or worsen. In that case, the treatment schedule should be re-evaluated immediately by a physician.

Do I need a prescription to order Durezol?

Yes, a prescription is required from your physician to order Durezol.