0

Home > Drug Category > Hepatitis Medications > Holkira Pak and Equivalent

Holkira Pak Information

Holkira Pak (Dasabuvir Sodium/Omitasvir/Paritaprevir/Ritonavir) is used to treat hepatitis C in adults with damaged liver that is still functioning properly (compensated liver disease). It is used alone or with another antiviral medication called ribavirin. It is not used for all genotypes of hepatitis C virus as it was developed to target genotype 1 specifically, which is the most common type of hepatitis C virus. Hepatitis C is a potentially serious viral infection that damages the liver over time, leading to scarring (fibrosis), cirrhosis, liver failure, or even hepatocellular carcinoma if not treated. Holkira Pak combines four active ingredients, each belonging to different classes of direct-acting antiviral agents. Dasabuvir sodium is a non-nucleoside NS5B RNA polymerase inhibitor that prevents the virus from copying its RNA. Ombitasvir is an NS5A inhibitor that blocks replication and viral assembly. Paritaprevir is an NS3/4A protease inhibitor that stops the virus from processing essential proteins. Ritonavir, though not active against the hepatitis C virus itself, acts as a pharmacokinetic enhancer by boosting paritaprevir levels in the body for better effect. Holkira Pak basically targets multiple stages of the virus life cycle. It significantly reduces the chance of viral survival and resistance. This process allows the immune system to clear the infection and prevent further liver damage. Clinical studies have shown that this treatment can achieve cure rates of over 90% in many cases.

Holkira Pak Side Effects

Common side effects of this medication include feeling tired or weak, headache, itching, and nausea. Contact your doctor if these common side effects persist or worsen.

Holkira Pak can cause severe liver problems, especially in people with advanced cirrhosis (liver scarring). These severe liver problems can lead to the need for a liver transplant or can lead to death. Therefore, stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, hives, swelling of the face, mouth, tongue, lips, or throat;
• Low red blood cells;
• Severe or life-threatening skin rashes and blisters;
• Symptoms of liver damage such as worsening vomiting, nausea, yellow eyes and skin, a change in the color of stool and urine, and body weakness

Inform your doctor about any other side effects you notice that are not listed here.

Holkira Pak Precautions

Do not use this medicine if you are allergic to the active and inactive ingredients in Holkira Pak or any other medicine. Before using this medication, ensure you inform your doctor about any medical conditions you previously or currently have, including the following:
• Hepatitis B infection;
• History of kidney or liver transplant;
• HIV infection;
• Severe liver problems

Ensure you know your hepatitis B status before taking this medication, as Holkira Pak can increase the activity of Hepatitis B infection, leading to liver damage and death. Check with your doctor regularly while taking this medication, as you may need to do some blood tests to check your liver function. Do not use this medication during pregnancy, especially if you are combining it with ribavirin, as it can harm the fetus. Ensure you use an effective birth control method while taking this medication, and for 6 months after stopping this antiviral drug. However, do not use birth control pills that contain estrogen, as it can affect the efficacy of Holkira Pak. Do not breastfeed while taking this medication. Kindly note that you can still pass on the hepatitis C infection to others while taking this medication. Therefore, talk with your doctor about ways to avoid passing on the infection. This medicine is not for use in children. Medications like amiodarone, birth control pills containing estradiol, everolimus, fentanyl, rilpivirine, and tacrolimus can interact negatively with Holkira Pak. Therefore, inform your doctor about all the medications, including herbal supplements, you are taking before using Holkira Pak to minimize the risk of interactions.

Take Holkira Pak tablets orally with meals as directed by your doctor. For most patients, the regimen involves a specific number of tablets taken twice a day, usually for 12 weeks. Your doctor will determine the appropriate dose and treatment schedule for you, depending on your liver condition and whether you are also prescribed other medications like ribavirin. Following the full course of treatment as directed is crucial for effectiveness. Check out the leaflet in the medication pack for more usage instructions. Store this medication at room temperature and keep it out of the reach of children.

Do I need a prescription to order Holkira Pak?

Yes, a prescription is required from your physician to order Holkira Pak.