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Prempro Information

Prempro (Conjugated Estrogens + Medroxyprogesterone) is a medication used mainly to treat moderate to severe symptoms of menopause, such as hot flashes, vaginal dryness, and night sweats. It is also used to help prevent osteoporosis in postmenopausal women who are at significant risk and cannot take other treatments. The medication is meant for women who still have their uterus, as it combines estrogen therapy with a progestin to protect the uterine lining. Prempro is a hormone replacement therapy whose active ingredients are conjugated estrogens and medroxyprogesterone acetate. Conjugated estrogens belong to the estrogen class of hormones, while medroxyprogesterone is a synthetic form of progesterone, a progestin. During menopause, the ovaries stop producing adequate levels of estrogen and progesterone. This hormonal drop can cause various symptoms and contribute to bone loss. Prempro works by replacing these hormones. Estrogen helps reduce hot flashes and other discomforts. At the same time, medroxyprogesterone lowers the risk of endometrial hyperplasia, which can occur when estrogen is given alone to women with a uterus. Hormone replacement therapies such as Prempro are not suitable for everyone. They are usually prescribed for the shortest possible time based on individual risk factors.

Prempro Side Effects

Some milder side effects of this medication include headache, breast pain, irregular vaginal bleeding, abdominal discomfort, nausea, vomiting, fluid retention, and vaginal yeast infection.

There may be a slightly increased risk of breast cancer, cervical cancer, and dementia, cardiovascular diseases such as stroke, heart attack, and pulmonary embolism, with long-term use of estrogen plus progestin medications. This risk is significantly high in women above 35 years who smoke. Therefore, stop taking this medicine and contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reactions such as breathing difficulties, hives, swelling of the face, lips, or throat;
• Breast lumps;
• Changes in speech;
• Changes in vision;
• Chest pain;
• Dizziness and faintness;
• Pain in your legs;
• Severe headaches;
• Severe nausea and vomiting;
• Unusual vaginal bleeding;
• Yellowing of the skin, eyes, or nail beds

Inform your doctor about any other side effects you notice that are not listed here.

Prempro Precautions

Do not use this medicine if you are allergic to conjugated estrogens and medroxyprogesterone acetate, or any other ingredients in Prempro. Before using this medication, ensure you inform your doctor about any medical conditions you previously or currently have, including the following:
• Blood clotting disorders;
• Breast or cervical cancer or any other cancers of the body;
• Chronic or heavy smoking;
• Depression;
• Diabetes;
• Epilepsy;
• Eye problems;
• Fibroids;
• Gallbladder disease;
• Heart disease;
• Hereditary or acquired angioedema;
• High blood pressure;
• High cholesterol in the blood;
• Inflammatory bowel disease, such as ulcerative colitis;
• Liver disease;
• Migraine headaches;
• Pancreatitis;
• Stroke;
• Thyroid problems;
• Undiagnosed abnormal vaginal bleeding

Avoid smoking while taking this medication, as smoking can increase the risk of blood clots, stroke, and other serious side effects, especially in women older than 35 years. Inform your doctor that you are taking this medication before undergoing any major surgery. Avoid prolonged bed rest while using this medicine to avoid blood clot disorders. It's advised to learn how to perform a self-breast examination. If you ever feel a lump, please inform your doctor immediately. Additionally, schedule regular doctor's appointments to help detect any serious side effects. This medication is not suitable for use during pregnancy or while breastfeeding. Prempro may interact with other drugs or substances, such as anastrozole, cimetidine, clarithromycin, fezolinetant, and ospemifene. Therefore, inform your healthcare provider about all the medicines, including herbal supplements, that you are taking before starting Prempro to prevent potential drug interactions.

Take Prempro by mouth once daily, preferably at the same time each day. Swallow the tablet whole with water and do not crush or chew it. Follow your doctor's instructions closely and use the lowest effective dose for the shortest time needed to manage your symptoms. Refer to the leaflets in the medication pack for additional usage instructions. Store this medication at room temperature and keep it out of the reach of children and pets.

Do I need a prescription to order Prempro?

Yes, a prescription is required from your physician to order Prempro.