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Home > Drug Category > Asthma Medication/ Respiratory Disorders > Yupelri and Equivalent

Yupelri Information

Yupelri (Revefenacin) is used in the treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It is used for maintenance treatment, to relax the airway and prevent sudden and acute exacerbation of this condition. Chronic obstructive pulmonary disease is a progressive and irreversible disease of the lungs that makes it hard to breathe due to blocked airflow resulting from long-term inflammation and damage to the lungs. It causes symptoms such as cough, wheezing, difficulty in breathing and chest discomfort. Yupelri’s active ingredient is revefenacin, which belongs to the class of medications called long-acting muscarinic antagonists. Revefenacin works by blocking muscarinic receptors (specifically M3) in the airways, which are implicated in airway narrowing and mucus production. By blocking these receptors, it relaxes the muscles surrounding the airways, widens the air passages, and reduces mucus production. These actions help to reduce coughing, wheezing, difficulty in breathing and other symptoms of COPD make it easier for patients living with this condition to breathe more easily. Yupelri is, however, not for use in treating acute attacks of COPD as it has not been proven to be effective in providing relief for acute onset of COPD symptoms.

Yupelri Side Effects

Like all medications, revefenacin has a range of potential side effects. Some common mild side effects of this medicine include cough, headache, runny nose, back pain, and upper respiratory tract infection. Contact your doctor immediately if you experience any serious side effects, including the following:
• Allergic reaction, such as hives, swelling of the face, lips, or throat;
• Eye problems such as blurry vision, red eyes, eye pain, or halos around light;
• Difficulty and pain when passing urine, frequent urination, or weak urine stream;
• Severe nausea and vomiting;
• Worsening difficulty in breathing or wheezing

These are not all of the side effects of Yupelri. Always contact your doctor if you notice any unusual symptoms.

Yupelri Precautions

Do not use this inhaled medicine if you are allergic to revefenacin, or any other ingredients in Yupelri. Before using this Yupelri, it is essential to inform your doctor about any previous or current medical conditions you may have, especially the following:
• Eye problems such as glaucoma;
• Heart disease;
• Kidney disease;
• Liver disease;
• Urinating difficulties, including prostate and bladder problems

This medicine may, in some rare cases, cause sudden onset of an unanticipated difficulty in breathing (paradoxical bronchospasm). If this happens, use your rescue inhaler and seek immediate medical attention. Inform your doctor if your symptoms worsen while using this medicine. Consult your doctor before using this medicine during pregnancy or while breastfeeding. This medication is not for use in children. Revefenacin may interact with other drugs or substances, such as cyclosporine, rifampicin, and other antimuscarinic medications, including aclidinium and tiotropium. Therefore, inform your healthcare provider about all the medicines, including herbal supplements, that you are taking before starting Yupelri to prevent potential drug interactions. Yupelri comes in a ready-to-use solution vial for use via inhalation using a nebulizer. Use a standard jet nebulizer connected to an air compressor. Inhale the full dose in one session and clean the nebulizer afterward. Consult your doctor to determine the appropriate dose for you and refer to the leaflet in the medication pack for additional usage details. Store this medication at room temperature and keep it out of the reach of children and pets.

Do I need a prescription to order Yupelri?

Yes, a prescription is required from your physician to order Yupelri.