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Generic Manerix 100mg from Canada:

The generic Manerix 100mg comes from Canada manufactured by AA Pharma in Canada. It is available in the quantity of 100 tablets.

Manerix (Moclobemide) Information

Manerix (moclobemide) is a prescription medication used primarily to treat Major Depressive Disorder (MDD) and Social Anxiety Disorder (SAD) (Social Phobia) in adults. It belongs to a unique class of antidepressants known as Reversible Inhibitors of Monoamine Oxidase-A (RIMA). This mechanism distinguishes it from older, irreversible Monoamine Oxidase Inhibitors (MAOIs), which are associated with severe dietary restrictions. Moclobemide's pharmacological profile allows it to effectively elevate mood and reduce anxiety while offering a better safety margin regarding hypertensive reactions. It is a potent antidepressant, but like all drugs in this class, it requires consistent daily dosing, and the full therapeutic effect may take several weeks to materialize.

The mechanism of action for moclobemide involves its selective and reversible inhibition of the enzyme Monoamine Oxidase A (MAO-A). MAO-A is responsible for the metabolism and breakdown of key monoamine neurotransmitters, including serotonin (5-HT) and norepinephrine (NE). By temporarily blocking MAO-A, moclobemide prevents the degradation of these neurotransmitters, leading to increased concentrations in the synaptic clefts of the brain. This enhanced concentration and subsequent increase in monoaminergic signalling are believed to be the primary mechanisms for its antidepressant and anxiolytic effects. The key to its safety profile lies in the "reversible" nature of its binding; if a patient ingests a large amount of tyramine (a substance that raises blood pressure), the moclobemide can quickly detach from the enzyme, allowing the MAO-A to metabolize the tyramine and thus prevent a severe hypertensive crisis. Manerix is available in Canada as a prescription-only tablet for use in adults 18 years of age and older. The dose is highly individualized and is typically taken two to three times daily, preferably with food, to improve absorption and tolerability. The usual starting dose is 300 mg per day, which is then gradually increased, if necessary, up to a maximum of 600 mg per day, based on the patient's response.

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Do I need a prescription to order Moclobemide 100 mg ?

Yes, a prescription is required from your physician to order Moclobemide 100 mg.